Intrathecal cytokines in spinal cord schistosomiasis

被引：9

作者：

Abreu Ferrari, Teresa Cristina

Rocha Moreira, Paulo Roberto

Sampaio, Marcio Jose

da Cunha, Aloisio Sales

de Oliveira, Jose Teotonio

Gazzinelli, Giovanni

Correa-Oliveira, Rodrigo

机构：

[1] Univ Fed Minas Gerais, Fac Med, Dept Clin Med, BR-30130100 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Hosp Clin, Neurol Serv, BR-30130100 Belo Horizonte, MG, Brazil

[3] Fiocruz MS, Ctr Pesquisas Rene Rachou, Lab Imunol Celular & Mol, BR-30190002 Belo Horizonte, MG, Brazil

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2006年 / 177卷 / 1-2期

关键词：

neuroschistosomiasis; spinal cord disease; cytokines; cerebrospinal fluid; Schistosoma mansoni;

D O I：

10.1016/j.jneuroim.2006.05.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigate the cytokine profile in the cerebrospinal fluid (CSF) and serum of patients with spinal cord schistosomiasis (SCS). Increased levels of IL-1 beta, IL-4, IL-6 and IL-10 and low concentrations of TNF-alpha and IFN-gamma were observed in both CSF and serum. CSF showed higher levels of IL-4 and IL-6 when compared to the paired serum samples. A negative correlation between the concentrations of IL-10 and IFN-gamma was observed in the CSF. These findings suggest an inflammatory as well as a skewed type-2 immune response that probably occur both locally and systemically and may be involved in the pathogenesis of SCS. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：136 / 141

页数：6

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