Intrathecal cytokines in spinal cord schistosomiasis

被引：9
|
作者：
Abreu Ferrari, Teresa Cristina
Rocha Moreira, Paulo Roberto
Sampaio, Marcio Jose
da Cunha, Aloisio Sales
de Oliveira, Jose Teotonio
Gazzinelli, Giovanni
Correa-Oliveira, Rodrigo
机构：
[1] Univ Fed Minas Gerais, Fac Med, Dept Clin Med, BR-30130100 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Hosp Clin, Neurol Serv, BR-30130100 Belo Horizonte, MG, Brazil
[3] Fiocruz MS, Ctr Pesquisas Rene Rachou, Lab Imunol Celular & Mol, BR-30190002 Belo Horizonte, MG, Brazil
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2006年 / 177卷 / 1-2期
关键词：
neuroschistosomiasis; spinal cord disease; cytokines; cerebrospinal fluid; Schistosoma mansoni;
D O I：
10.1016/j.jneuroim.2006.05.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigate the cytokine profile in the cerebrospinal fluid (CSF) and serum of patients with spinal cord schistosomiasis (SCS). Increased levels of IL-1 beta, IL-4, IL-6 and IL-10 and low concentrations of TNF-alpha and IFN-gamma were observed in both CSF and serum. CSF showed higher levels of IL-4 and IL-6 when compared to the paired serum samples. A negative correlation between the concentrations of IL-10 and IFN-gamma was observed in the CSF. These findings suggest an inflammatory as well as a skewed type-2 immune response that probably occur both locally and systemically and may be involved in the pathogenesis of SCS. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：136 / 141
页数：6
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