Triterpenoids with anti-tobacco mosaic virus activities from Melia Toosendan

被引：18

作者：

Chen, Lin ^{[1
,2
,3
]}

Zhang, Jian-Xin ^{[2
,3
]}

Wang, Bin ^{[2
,3
]}

Mu, Shu-Zhen ^{[2
,3
]}

Hao, Xiao-Jiang ^{[2
,3
]}

机构：

[1] Guizhou Univ, Coll Pharm, Guiyang 550025, Peoples R China

[2] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Guizhou, Peoples R China

[3] Chinese Acad Sci, Guiyang 550002, Peoples R China

来源：

FITOTERAPIA | 2014年 / 97卷

关键词：

Melia toosendan; Triterpenoids; Limonoids; Anti-tobacco mosaic virus activities; LIMONOIDS;

D O I：

10.1016/j.fitote.2014.06.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new triterpenoids, named Toosendansins A-D (1-4), along with nine known ones (5-13) were isolated from the fruits of Melia toosendan Sieb. et Zucc. Their structures were established on the basis of spectroscopic data. The isolation of compounds 1-12 were reported for the first time from this plant. All compounds were analyzed for the anti-Tobacco Mosaic Virus (TMV) activity and protective effect on H2O2-induced damage of SH-SY5Y cells. Compound 7 showed evident anti-TMV activity. Compounds 2 and 9 exhibited modest protection against H2O2-induced damage of SH-SY5Y cells. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：204 / 210

页数：7

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