Triterpenoids with anti-tobacco mosaic virus activities from Melia Toosendan

被引：18
|
作者：
Chen, Lin [1 ,2 ,3 ]
Zhang, Jian-Xin [2 ,3 ]
Wang, Bin [2 ,3 ]
Mu, Shu-Zhen [2 ,3 ]
Hao, Xiao-Jiang [2 ,3 ]
机构：
[1] Guizhou Univ, Coll Pharm, Guiyang 550025, Peoples R China
[2] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Guizhou, Peoples R China
[3] Chinese Acad Sci, Guiyang 550002, Peoples R China
来源：
FITOTERAPIA | 2014年 / 97卷
关键词：
Melia toosendan; Triterpenoids; Limonoids; Anti-tobacco mosaic virus activities; LIMONOIDS;
D O I：
10.1016/j.fitote.2014.06.010
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new triterpenoids, named Toosendansins A-D (1-4), along with nine known ones (5-13) were isolated from the fruits of Melia toosendan Sieb. et Zucc. Their structures were established on the basis of spectroscopic data. The isolation of compounds 1-12 were reported for the first time from this plant. All compounds were analyzed for the anti-Tobacco Mosaic Virus (TMV) activity and protective effect on H2O2-induced damage of SH-SY5Y cells. Compound 7 showed evident anti-TMV activity. Compounds 2 and 9 exhibited modest protection against H2O2-induced damage of SH-SY5Y cells. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：204 / 210
页数：7
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