Inhibition of mast cell degranulation by tanshinones from the roots of Salvia miltiorrhiza

被引：53
|
作者：
Ryu, SY
Oak, MH
Kim, KM [1 ]
机构：
[1] Chonnam Natl Univ, Coll Pharm, Pharmacol Lab, Kwang Ju, Kwangju 500757, South Korea
[2] Korea Res Inst Chem Technol, Taejon 305606, South Korea
来源：
PLANTA MEDICA | 1999年 / 65卷 / 07期
关键词：
D O I：
10.1055/s-2006-960839
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The activity-guided fractionation of the extract of the root of Salvia miltiorrhiza B. (Labiatae, Tanshen), led to the isolation of four active components responsible for the anti-allergic activity in vitro. Among them, 15,16-dihydrotanshinone-1 and cryptotanshinone demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells in a dose-dependent manner; the ICS, values were calculated as 16 and 36 mu M, respectively.
引用
收藏
页码：654 / 655
页数：2
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