Inhibition of mast cell degranulation by tanshinones from the roots of Salvia miltiorrhiza

被引：53

作者：

Ryu, SY

Oak, MH

Kim, KM ^{[1
]}

机构：

[1] Chonnam Natl Univ, Coll Pharm, Pharmacol Lab, Kwang Ju, Kwangju 500757, South Korea

[2] Korea Res Inst Chem Technol, Taejon 305606, South Korea

来源：

PLANTA MEDICA | 1999年 / 65卷 / 07期

关键词：

D O I：

10.1055/s-2006-960839

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The activity-guided fractionation of the extract of the root of Salvia miltiorrhiza B. (Labiatae, Tanshen), led to the isolation of four active components responsible for the anti-allergic activity in vitro. Among them, 15,16-dihydrotanshinone-1 and cryptotanshinone demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells in a dose-dependent manner; the ICS, values were calculated as 16 and 36 mu M, respectively.

引用

页码：654 / 655

页数：2

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