Therapy Resistant CML Stem Cells Are Dependent on Mitochondrial Oxidative Metabolism for Their Survival

被引:2
|
作者
Kuntz, Elodie Marie [1 ]
Baquero, Pablo [2 ]
Holyoake, Tessa L. [3 ]
Gottlieb, Eyal [1 ]
Helgason, G. Vignir [2 ]
机构
[1] Canc Res UK, Beatson Inst, Glasgow, Lanark, Scotland
[2] Univ Glasgow, Wolfson Wohl Canc Res Ctr, Glasgow, Lanark, Scotland
[3] Univ Glasgow, Paul OGorman Leukaemia Res Ctr, Glasgow, Lanark, Scotland
关键词
D O I
10.1182/blood.V128.22.932.932
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
932
引用
收藏
页数:4
相关论文
共 50 条
  • [1] Glucose and glutamine in the mitochondrial oxidative metabolism of stem cells
    Nesci, Salvatore
    [J]. MITOCHONDRION, 2017, 35 : 11 - 12
  • [2] Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells
    Chung S.
    Dzeja P.P.
    Faustino R.S.
    Perez-Terzic C.
    Behfar A.
    Terzic A.
    [J]. Nature Clinical Practice Cardiovascular Medicine, 2007, 4 (Suppl 1): : S60 - S67
  • [3] Inhibition of Folate Metabolism Drives Autophagy-Dependent Differentiation and Reduces Survival of Therapy-Resistant Leukaemic Stem Cells
    M.Zarou, Martha
    Rattigan, Kevin
    Brabcova, Zuzana
    Dawson, Amy
    Sumpton, David
    Vazquez, Alexei
    Helgason, Vignir
    [J]. BLOOD, 2021, 138
  • [4] Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
    Elodie M Kuntz
    Pablo Baquero
    Alison M Michie
    Karen Dunn
    Saverio Tardito
    Tessa L Holyoake
    G Vignir Helgason
    Eyal Gottlieb
    [J]. Nature Medicine, 2017, 23 : 1234 - 1240
  • [5] Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
    Kuntz, Elodie M.
    Baquero, Pablo
    Michie, Alison M.
    Dunn, Karen
    Tardito, Saverio
    Holyoake, Tessa L.
    Helgason, G. Vignir
    Gottlieb, Eyal
    [J]. NATURE MEDICINE, 2017, 23 (10) : 1234 - +
  • [6] Inhibition of PAK6-Mediated Survival and Cell Cycle Controls Selectively Targets Therapy-Resistant CML Stem/Progenitor Cells
    Wu, Andrew
    Chen, Min
    Yen, Ryan
    Jiang, Xiaoyan
    [J]. BLOOD, 2020, 136
  • [7] Auto-Commentary on: "Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells"
    de Beauchamp, Lucie
    Baquero, Pablo
    Kuntz, Elodie M.
    Gottlieb, Eyal
    Helgason, G. Vignir
    [J]. MOLECULAR & CELLULAR ONCOLOGY, 2018, 5 (01):
  • [8] Low c-Kit expression identifies primitive, therapy-resistant CML stem cells
    Shah, Mansi
    Kumar, Harish
    Qiu, Shaowei
    Li, Hui
    Harris, Mason
    He, Jianbo
    Abraham, Ajay
    Crossman, David K.
    Paterson, Andrew
    Welner, Robert S.
    Bhatia, Ravi
    [J]. JCI INSIGHT, 2023, 8 (01)
  • [9] Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress
    Pfeiffer, Annika
    Jaeckel, Martin
    Lewerenz, Jan
    Noack, Rebecca
    Pouya, Alireza
    Schacht, Teresa
    Hoffmann, Christina
    Winter, Jennifer
    Schweiger, Susann
    Schaefer, Michael K. E.
    Methner, Axel
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2014, 171 (08) : 2147 - 2158
  • [10] Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function
    Viale, Andrea
    Pettazzoni, Piergiorgio
    Lyssiotis, Costas
    Ying, Haoqiang
    Sanchez, Nora
    Marchesini, Matteo
    Carugo, Alessandro
    Green, Tessa
    Seth, Sahil
    Giuliani, Virginia
    Heffernan, Timothy
    Kimmelman, Alec
    Wang, Huamin
    Fleming, Jason
    Cantley, Lewis
    DePinho, Ronald
    Draetta, Giulio
    [J]. CANCER RESEARCH, 2015, 75