Auto-Commentary on: "Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells"

被引：4

作者：

de Beauchamp, Lucie ^{[1
]}

Baquero, Pablo ^{[1
]}

Kuntz, Elodie M. ^{[2
]}

Gottlieb, Eyal ^{[2
,3
]}

Helgason, G. Vignir ^{[1
]}

机构：

[1] Univ Glasgow, Coll Med Vet & Life Sci, Inst Canc Sci, Wolfson Wohl Canc Res Ctr, Glasgow, Lanark, Scotland

[2] Canc Res UK, Beatson Inst, Garscube Estate,Switchback Rd, Glasgow, Lanark, Scotland

[3] Technion Israel Inst Technol, Fac Med, Technion Integrated Canc Ctr, Haifa, Israel

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 01期

关键词：

Cancer stem cells; CML; Metabolism; Imatinib; Leukaemia; OXPHOS; Tyrosine kinase inhibitor; Tigecycline; TCA cycle;

D O I：

10.1080/23723556.2017.1403532

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-resistant chronic myeloid leukaemia stem cells (LSCs). By simultaneously disrupting mitochondrial respiration and inhibiting BCR-ABL kinase activity using the antibiotic tigecycline and imatinib respectively, we effectively eradicated LSCs and prevented disease relapse in pre-clinical animal models.

引用

页数：3

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