Inhibition of PAK6-Mediated Survival and Cell Cycle Controls Selectively Targets Therapy-Resistant CML Stem/Progenitor Cells

被引:1
|
作者
Wu, Andrew
Chen, Min
Yen, Ryan
Jiang, Xiaoyan
机构
关键词
D O I
10.1182/blood-2020-140459
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:2
相关论文
共 5 条
  • [1] Inhibition of the MiR-185-PAK6-Mediated Survival and Metabolic Pathways Selectively Targets Drug-Resistant CML Stem/Progenitor Cells
    Wu, Andrew
    Rothe, Katharina
    Chen, Min
    Lin, Hanyang
    Babaian, Artem
    Yen, Ryan
    Forrest, Donna L.
    Jiang, Xiaoyan
    [J]. BLOOD, 2019, 134
  • [2] The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML
    Lin, Hanyang
    Rothe, Katharina
    Chen, Min
    Wu, Andrew
    Babaian, Artem
    Yen, Ryan
    Zeng, Jonathan
    Ruschmann, Jens
    Petriv, Oleh I.
    O'Neill, Kieran
    Maetzig, Tobias
    Knapp, David J. H. F.
    Nakamichi, Naoto
    Brinkman, Ryan
    Birol, Inanc
    Forrest, Donna L.
    Hansen, Carl
    Humphries, R. Keith
    Eaves, Connie J.
    Jiang, Xiaoyan
    [J]. BLOOD, 2020, 136 (05) : 596 - 609
  • [3] Inhibition of Folate Metabolism Drives Autophagy-Dependent Differentiation and Reduces Survival of Therapy-Resistant Leukaemic Stem Cells
    M.Zarou, Martha
    Rattigan, Kevin
    Brabcova, Zuzana
    Dawson, Amy
    Sumpton, David
    Vazquez, Alexei
    Helgason, Vignir
    [J]. BLOOD, 2021, 138
  • [4] Ponatinib and inhibition of the PI3K/Akt/mTOR pathway induces cell death and protective autophagy in TKI-resistant CML stem/progenitor cells
    Helgason, G. V.
    Allan, E.
    Galavotti, S.
    Audia, A.
    Hamilton, A.
    Mukhopadhyay, A.
    Karvela, M.
    Salomoni, P.
    Calabretta, B.
    Holyoake, T. L.
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2012, 157 : 1 - 1
  • [5] Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition
    Wu, Raymond
    Murali, Ramachandran
    Kabe, Yasuaki
    French, Samuel W.
    Chiang, Yi-Ming
    Liu, Siyu
    Sher, Linda
    Wang, Clay C.
    Louie, Stan
    Tsukamoto, Hidekazu
    [J]. HEPATOLOGY, 2018, 68 (05) : 1726 - 1740