Geranyl chalcone derivatives with antifungal and radical scavenging properties from the leaves of Artocarpus nobilis

被引：88

作者：

Jayasinghe, L

Balasooriya, BAIS

Padmini, WC

Hara, N

Fujimoto, Y

机构：

[1] Inst Fundamental Studies, Kandy, Sri Lanka

[2] Tokyo Inst Technol, Dept Chem & Mat Sci, Meguro Ku, Tokyo 1528551, Japan

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 09期

关键词：

Artocarpus nobilis; moraceae; chalcones; antifungal; Cladosporium cladosporioides; radical scavenging; DPPH;

D O I：

10.1016/j.phytochem.2004.03.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antifungal activity guided fractionation of the n-butanol extract from the methanol extract of the leaves of Artocarpus nobilis furnished 2',4',4-trihydroxy-3'-geranylchalcone (1), 2',41,4-trihydroxy-3'-[6-hydroxy-3,7-dimethyl-2(E),7-octadienyl]chalcone (2), 2, 4',4-trihydroxy-3'-[2-hydroxy-7-methyl-3-methylene-6-octaenyl]chalcone (3), 2',3,4,4'-tetrahydroxy-3-geranylchalcone (4), 2',3,4,4'-tetrahydroxy-3'-[6-hydroxy-3,7-dimethyl-2(E),7-octadienyl]chalcone (5). The chalcones 3 and 5 are new natural products whereas 1 and 2 are reported first time from the family Moraceae. All these compounds showed good fungicidal activity against Cladosporium cladosporioides and high radical scavenging activity towards the 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical in TLC bio-autography method. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1287 / 1290

页数：4

共 50 条

[21] Synthesis of Some N, N'-Diacylhydrazine Derivatives with Radical-Scavenging and Antifungal Activity
Liu, Xing-Hai
Shi, Yan-Xia
Ma, Yi
He, Guo-Rong
Dong, Wei-Li
Zhang, Chuan-Yu
Wang, Bao-Lei
Wang, Su-Hua
Li, Bao-Ju
Li, Zheng-Ming
[J]. CHEMICAL BIOLOGY & DRUG DESIGN, 2009, 73 (03) : 320 - 327
[22] Phytochemical analysis, antimicrobial and radical-scavenging properties of Acalypha manniana leaves
Noumedem, Jaures A. K.
Tamokou, Jean de Dieu
Teke, Gerald Ngo
Momo, Rosine C. D.
Kuete, Victor
Kuiate, Jules Roger
[J]. SPRINGERPLUS, 2013, 2 : 1 - 6
[23] Synthesis of dihydroxylated chalcone derivatives with diverse substitution patterns and their radical scavenging ability toward DPPH free radicals
Kim, Beom-Tae
Kwang-Joong, O.
Chun, Jae-Chul
Hwang, Ki-Jun
[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2008, 29 (06) : 1125 - 1130
[24] Radical scavenging conserves from unused fresh green tea leaves
Borse, B. B.
Kumar, H. Vijay
Rao, L. Jagan Mohan
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (05) : 1750 - 1754
[25] Free Radical Scavenging and Hepatoprotective Constituents from the Leaves of Juglans sinensis
Ren-Bo An
Hyun-Chul Kim
Yu-Hua Tian
Youn-Chul Kim
[J]. Archives of Pharmacal Research, 2005, 28 : 529 - 533
[26] Free radical scavenging and hepatoprotective constituents from the leaves of Juglans sinensis
An, RB
Kim, HC
Tian, YH
Kim, YC
[J]. ARCHIVES OF PHARMACAL RESEARCH, 2005, 28 (05) : 529 - 533
[27] Secoiridoid glucosides with free radical scavenging activity from the leaves of Syringa dilatata
Oh, H
Ko, EK
Kim, DH
Jang, KK
Park, SE
Lee, HS
Kim, YC
[J]. PHYTOTHERAPY RESEARCH, 2003, 17 (04) : 417 - 419
[28] Flavonoids with free radical scavenging activity and nitric oxide inhibitory effect from the stem bark of Artocarpus gomezianus
Sritularak, B.
Tantituvanont, A.
Chanvorachote, P.
Meksawan, K.
Miyamoto, T.
Kohno, Y.
Likhitwitayawuid, K.
[J]. JOURNAL OF MEDICINAL PLANTS RESEARCH, 2010, 4 (05): : 387 - 392
[29] Effects of Functional Groups and Sugar Composition of Quercetin Derivatives on Their Radical Scavenging Properties
Kato, Komei
Ninomiya, Masayuki
Tanaka, Kaori
Koketsu, Mamoru
[J]. JOURNAL OF NATURAL PRODUCTS, 2016, 79 (07): : 1808 - 1814
[30] DFT study on the radical scavenging properties of anticancer hydroxyurea and hydroxybenzohydroxamic acid derivatives
Bayat, Ahmad
Fattahi, Alireza
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244

← 1 2 3 4 5 →