Antibacterial mechanism of oregano essential oil

被引：205

作者：

Cui, Haiying ^{[1
]}

Zhang, Chenghui ^{[1
]}

Li, Changzhu ^{[2
]}

Lin, Lin ^{[1
]}

机构：

[1] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China

[2] Hunan Acad Forestry, Dept Bioresource, Changsha 410007, Hunan, Peoples R China

来源：

INDUSTRIAL CROPS AND PRODUCTS | 2019年 / 139卷

基金：

中国国家自然科学基金;

关键词：

MRSA; Oregano essential oil; Antibacterial mechanism; Oxidative respiratory metabolism; Pvl gene; SALMONELLA; MRSA;

D O I：

10.1016/j.indcrop.2019.111498

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Meticillin-resistant Staphylococcus aureus (MRSA) is highly pathogenic and multi-drug resistant, so MRSA infection has become one of the important pathogens of nosocomial infections. Oregano essential oil is an effective natural antibacterial agent and has been found to be effective in inhibiting MRSA. In this experiment, the effects of oregano essential oil on respiratory metabolism, energy metabolism and genetic material of MRSA were studied with the metabolism as the starting point. At the same time, the effects of oregano essential oil on the relative expression of pvl in MRSA were further studied from the genetic level. The results indicate that oregano essential oil can cause irreversible damage to the MRSA cell membrane and cause leakage of biological macromolecules in the cell. Oregano essential oil inhibits the tricarboxylic acid cycle pathway and its key enzymes and affects the metabolites. In addition, the main component of oregano essential oil, carvacrol, can be chimeric with DNA, and oregano essential oil inhibits the relative expression of the pvl gene.

引用

页数：9

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