Exploring the Link between the Germline and Somatic Genome in Cancer

被引:6
|
作者
Geeleher, Paul [1 ]
Huang, R. Stephanie [1 ]
机构
[1] Univ Chicago, Dept Med, Hematol Oncol Sect, Chicago, IL 60637 USA
关键词
BREAST-CANCER; SUSCEPTIBILITY LOCI; METAANALYSES; ASSOCIATION;
D O I
10.1158/2159-8290.CD-17-0192
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Summary: Carter and colleagues propose a systematic analysis of the germline and somatic genome in cancer. They identify interactions that occur between germline and somatic variants. This elucidates the function of the germline genome in the context of cancer risk and development © 2017 American Association for Cancer Research.
引用
收藏
页码:354 / 355
页数:2
相关论文
共 50 条
  • [31] Integrated analysis of germline and somatic variants in ovarian cancer
    Krishna L. Kanchi
    Kimberly J. Johnson
    Charles Lu
    Michael D. McLellan
    Mark D. M. Leiserson
    Michael C. Wendl
    Qunyuan Zhang
    Daniel C. Koboldt
    Mingchao Xie
    Cyriac Kandoth
    Joshua F. McMichael
    Matthew A. Wyczalkowski
    David E. Larson
    Heather K. Schmidt
    Christopher A. Miller
    Robert S. Fulton
    Paul T. Spellman
    Elaine R. Mardis
    Todd E. Druley
    Timothy A. Graubert
    Paul J. Goodfellow
    Benjamin J. Raphael
    Richard K. Wilson
    Li Ding
    Nature Communications, 5
  • [32] Exploring the Cancer Genome
    Rouzer, Carol A.
    CHEMICAL RESEARCH IN TOXICOLOGY, 2010, 23 (04) : 710 - 711
  • [33] Identifying disparities in germline and somatic testing for ovarian cancer
    Huang, Marilyn
    Kamath, Priyanka
    Schlumbrecht, Matthew
    Miao, Feng
    Driscoll, Devin
    Oldak, Sean
    Slomovitz, Brian
    Koru-Sengul, Tulay
    George, Sophia
    GYNECOLOGIC ONCOLOGY, 2019, 153 (02) : 297 - 303
  • [34] Germline and somatic genetic testing in ovarian cancer patients
    Chandrasekaran, D.
    Manchanda, R.
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2018, 125 (11) : 1460 - 1460
  • [35] Germline and Somatic mutations in postmenopausal breast cancer patients
    Nagy, Tauana Rodrigues
    Maistro, Simone
    Encinas, Giselly
    Hirata Katayama, Maria Lucia
    de Lima Pereira, Glaucia Fernanda
    Gaburo-Junior, Nelson
    Moyses Franco, Lucas Augusto
    Ribeiro Chaves de Gouvea, Ana Carolina
    Estevez Diz, Maria del Pilar
    Senna Leite, Luiz Antonio
    Azevedo Koike Folgueira, Maria Aparecida
    CLINICS, 2021, 76
  • [36] Integrated analysis of germline and somatic variants in ovarian cancer
    Kanchi, Krishna L.
    Johnson, Kimberly J.
    Lu, Charles
    McLellan, Michael D.
    Leiserson, Mark D. M.
    Wendl, Michael C.
    Zhang, Qunyuan
    Koboldt, Daniel C.
    Xie, Mingchao
    Kandoth, Cyriac
    McMichael, Joshua F.
    Wyczalkowski, Matthew A.
    Larson, David E.
    Schmidt, Heather K.
    Miller, Christopher A.
    Fulton, Robert S.
    Spellman, Paul T.
    Mardis, Elaine R.
    Druley, Todd E.
    Graubert, Timothy A.
    Goodfellow, Paul J.
    Raphael, Benjamin J.
    Wilson, Richard K.
    Ding, Li
    NATURE COMMUNICATIONS, 2014, 5
  • [37] Germline and Somatic Tumor Testing in Gynecologic Cancer Care
    Alldredge, Jill
    Randall, Leslie
    OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, 2019, 46 (01) : 37 - +
  • [38] Germline and somatic mutations in prostate cancer: Implications for treatment
    Chalker, Cameron
    Chun, Brie
    Sokolova, Alexandra O.
    CURRENT PROBLEMS IN CANCER, 2024, 50
  • [39] WHOLE GENOME SEQUENCING ANALYSIS: EXPLORING GERMLINE CNV LANDSCAPES
    Ferreira, Marta
    Maqueda, Joaquin Jurado
    Almeida, Francisco
    Monteiro, Rita
    Jose, Celina Sao
    Oliveira, Carla
    MEDICINE, 2022, 101 (30)
  • [40] Germline variants from paired somatic-germline testing in pancreatic cancer.
    Funchain, Pauline
    Heald, Brandie
    White, Kevin
    Buschmann, Mary
    Roggin, Kevin K.
    Khorana, Alok A.
    Sohal, Davendra
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)