Behavioral sensitization to the discriminative stimulus effects of methamphetamine in rats

被引：28
|
作者：
Suzuki, T [1 ]
Fukuoka, Y [1 ]
Mori, T [1 ]
Miyatake, M [1 ]
Narita, M [1 ]
机构：
[1] Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Toxicol, Tokyo 1428501, Japan
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 498卷 / 1-3期
关键词：
drug discrimination; sensitization; methamphetamine;
D O I：
10.1016/j.ejphar.2004.07.064
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Sensitization to the discriminative stimulus effects of psychostimulants is not fully understood. Therefore, the present study was designed to investigate the development of sensitization to the discriminative stimulus of methamphetamine in rats. A dose response curve for methamphetamine and a generalization test for cocaine were recorded in rats trained to discriminate between 1.0 mg/kg methamphetamine and saline. A significant leftward shift of the dose-response curve for methamphetamine and of the dose-generalization curve for cocaine was observed following repeated administration of methamphetamine (2.0 mg/kg) instead of saline. These findings suggest that repeated administration of methamphetamine can produce behavioral sensitization to the discriminative stimulus effects of methamphetamine in rats. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：157 / 161
页数：5
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