Behavioral sensitization to the discriminative stimulus effects of methamphetamine in rats

被引：28
|
作者：
Suzuki, T [1 ]
Fukuoka, Y [1 ]
Mori, T [1 ]
Miyatake, M [1 ]
Narita, M [1 ]
机构：
[1] Hoshi Univ, Sch Pharm & Pharmaceut Sci, Dept Toxicol, Tokyo 1428501, Japan
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 498卷 / 1-3期
关键词：
drug discrimination; sensitization; methamphetamine;
D O I：
10.1016/j.ejphar.2004.07.064
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Sensitization to the discriminative stimulus effects of psychostimulants is not fully understood. Therefore, the present study was designed to investigate the development of sensitization to the discriminative stimulus of methamphetamine in rats. A dose response curve for methamphetamine and a generalization test for cocaine were recorded in rats trained to discriminate between 1.0 mg/kg methamphetamine and saline. A significant leftward shift of the dose-response curve for methamphetamine and of the dose-generalization curve for cocaine was observed following repeated administration of methamphetamine (2.0 mg/kg) instead of saline. These findings suggest that repeated administration of methamphetamine can produce behavioral sensitization to the discriminative stimulus effects of methamphetamine in rats. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：157 / 161
页数：5
相关论文
共 50 条
  • [21] Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds
    Yan, Yijin
    Nitta, Atsumi
    Mizuno, Tomoko
    Nakajima, Akira
    Yamada, Kiyofumi
    Nabeshima, Toshitaka
    BEHAVIOURAL BRAIN RESEARCH, 2006, 173 (01) : 39 - 46
  • [22] Discriminative-stimulus effects of second generation synthetic cathinones in methamphetamine-trained rats
    Naylor, Jennifer E.
    Freeman, Kevin B.
    Blough, Bruce E.
    Woolverton, William L.
    Huskinson, Sally L.
    DRUG AND ALCOHOL DEPENDENCE, 2015, 149 : 280 - 284
  • [23] Differential modulation of the discriminative stimulus effects of methamphetamine and cocaine by alprazolam and oxazepam in male and female rats
    Spence, A. L.
    Guerin, G. F.
    Goeders, N. E.
    NEUROPHARMACOLOGY, 2016, 102 : 146 - 157
  • [24] Discriminative stimulus effects of mexidol in rats
    Kalinina, TS
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2005, 15 : S140 - S141
  • [25] DISCRIMINATIVE STIMULUS EFFECTS OF ANANDAMIDE IN RATS
    WILEY, J
    BALSTER, R
    MARTIN, B
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 276 (1-2) : 49 - 54
  • [26] The discriminative stimulus effects of muscimol in rats
    Grech, DM
    Balster, RL
    PSYCHOPHARMACOLOGY, 1997, 129 (04) : 339 - 347
  • [27] Methamphetamine-like discriminative stimulus effects of nicotinic agonists
    Desai, Rajeev I.
    Trowel, Elise
    Bergman, Jack
    FASEB JOURNAL, 2011, 25
  • [28] Effects of chronic caffeine exposure on adenosinergic modulation of the discriminative-stimulus effects of nicotine, methamphetamine, and cocaine in rats
    Justinova, Zuzana
    Ferre, Sergi
    Barnes, Chanel
    Wertheim, Carrie E.
    Pappas, Lara A.
    Goldberg, Steven R.
    Le Foll, Bernard
    PSYCHOPHARMACOLOGY, 2009, 203 (02) : 355 - 367
  • [29] Effects of chronic caffeine exposure on adenosinergic modulation of the discriminative-stimulus effects of nicotine, methamphetamine, and cocaine in rats
    Zuzana Justinova
    Sergi Ferré
    Chanel Barnes
    Carrie E. Wertheim
    Lara A. Pappas
    Steven R. Goldberg
    Bernard Le Foll
    Psychopharmacology, 2009, 203
  • [30] Effects of histamine agents on methamphetamine-induced stereotyped behavior and behavioral sensitization in rats
    C. Ito
    K. Onodera
    T. Watanabe
    M. Sato
    Psychopharmacology, 1997, 130 : 362 - 367
12345