p53 and MDM2: Antagonists or Partners in Crime?

被引：34
|
作者：
Eischen, Christine M. [2 ]
Lozano, Guillermina [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA
[2] Vanderbilt Univ, Sch Med, Dept Pathol, Nashville, TN 37232 USA
来源：
CANCER CELL | 2009年 / 15卷 / 03期
关键词：
P21(WAF1/CIP1);
D O I：
10.1016/j.ccr.2009.02.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Therapeutics that disrupt the p53-MDM2 interaction show promise for cancer treatment but surprisingly have different biological outcomes. A study by Enge et al. in this issue of Cancer Cell shows that the ability of MDM2 to target hnRNP K for degradation contributes to the decision to induce apoptosis rather than cell-cycle arrest.
引用
收藏
页码：161 / 162
页数：2
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