p53 and MDM2: Antagonists or Partners in Crime?

被引：34

作者：

Eischen, Christine M. ^{[2
]}

Lozano, Guillermina ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA

[2] Vanderbilt Univ, Sch Med, Dept Pathol, Nashville, TN 37232 USA

来源：

CANCER CELL | 2009年 / 15卷 / 03期

关键词：

P21(WAF1/CIP1);

D O I：

10.1016/j.ccr.2009.02.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Therapeutics that disrupt the p53-MDM2 interaction show promise for cancer treatment but surprisingly have different biological outcomes. A study by Enge et al. in this issue of Cancer Cell shows that the ability of MDM2 to target hnRNP K for degradation contributes to the decision to induce apoptosis rather than cell-cycle arrest.

引用

页码：161 / 162

页数：2

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