Synthesis of the KLMN Fragment of Gymnocin-A from the FGH Fragment

被引：4
|
作者：
Sakai, Takeo [1 ]
Ishihara, Aoi [1 ]
Mori, Yuji [1 ]
机构：
[1] Meijo Univ, Fac Pharm, Tempaku Ku, 150 Yagotoyama, Nagoya, Aichi 4688503, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 07期
基金：
日本学术振兴会;
关键词：
TRANS-FUSED TETRAHYDROPYRANS; OXIRANYL ANION STRATEGY; RED TIDE DINOFLAGELLATE; POLYCYCLIC ETHERS; RING FRAGMENT; CONVERGENT STRATEGIES; CYTOTOXIC POLYETHER; MARINE POLYETHER; TOXINS; ACID;
D O I：
10.1021/acs.joc.7b00232
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An improved route for the synthesis of the KLMN fragment of gymnocin-A was developed through the oxiranyl anion coupling of the FGH fragment with a chiral C-3 epoxy sulfone, followed by 6-endo cyclization. This straightforward approach reduced the number of synthetic steps by 14 compared with a previous route, using alternative building blocks.
引用
收藏
页码：3976 / 3981
页数：6
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