Synthesis of the KLMN Fragment of Gymnocin-A from the FGH Fragment

被引：4

作者：

Sakai, Takeo ^{[1
]}

Ishihara, Aoi ^{[1
]}

Mori, Yuji ^{[1
]}

机构：

[1] Meijo Univ, Fac Pharm, Tempaku Ku, 150 Yagotoyama, Nagoya, Aichi 4688503, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 07期

基金：

日本学术振兴会;

关键词：

TRANS-FUSED TETRAHYDROPYRANS; OXIRANYL ANION STRATEGY; RED TIDE DINOFLAGELLATE; POLYCYCLIC ETHERS; RING FRAGMENT; CONVERGENT STRATEGIES; CYTOTOXIC POLYETHER; MARINE POLYETHER; TOXINS; ACID;

D O I：

10.1021/acs.joc.7b00232

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved route for the synthesis of the KLMN fragment of gymnocin-A was developed through the oxiranyl anion coupling of the FGH fragment with a chiral C-3 epoxy sulfone, followed by 6-endo cyclization. This straightforward approach reduced the number of synthetic steps by 14 compared with a previous route, using alternative building blocks.

引用

页码：3976 / 3981

页数：6

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