Synthesis of mixed-sequence oligonucleotides on mesoporous silicon: chemical strategies and material stability

被引：9

作者：

Terracciano, Monica ^{[1
,2
]}

Rea, Ilaria ^{[1
]}

Stefano, Luca De ^{[1
]}

Rendina, Ivo ^{[1
]}

Oliviero, Giorgia ^{[2
]}

Nici, Fabrizia ^{[2
]}

D'Errico, Stefano ^{[2
]}

Piccialli, Gennaro ^{[2
]}

Borbone, Nicola ^{[2
]}

机构：

[1] Inst Microelectron & Microsystems, Natl Res Council, I-80131 Naples, Italy

[2] Univ Naples Federico II, Dept Pharm, I-80138 Naples, Italy

来源：

NANOSCALE RESEARCH LETTERS | 2014年 / 9卷

关键词：

Mesoporous silicon functionalization; DNA synthesis; Deprotection conditions; Surface stability; POROUS SILICON; BIOSENSORS; SURFACE;

D O I：

10.1186/1556-276X-9-317

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Rapid screening tests in medical diagnostic and environmental analysis are often based on oligonucleotide biochips. In this paper, we studied the stability of functionalized mesoporous silicon supports in the solid-phase synthesis of oligonucleotides, exploiting several chemical procedures. A 19-mer mixed sequence has been successfully synthesized on aminosilane-modified porous silicon photonic structures. The process and the materials have been characterized by optical reflectivity, atomic force microscopy and high-performance liquid chromatography.

引用

页码：1 / 9

页数：9

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