Synthesis, biophysical properties, and stability studies of mixed backbone oligonucleotides containing novel non-ionic linkages

被引：1
|
作者：
Iyer, RP
Yu, D
Devlin, T
Ho, NH
Johnson, S
Agrawal, S
机构：
来源：
NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 7-9期
关键词：
D O I：
10.1080/07328319708006214
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mixed backbone oligonucleotides (MBOs) (containing ionic and nonionic internucleotidic linkages) in which the non-ionic segments are either methylphosphotriester (PO-OMe) or primary phosphoramidate (PO-NH2) linkages have been prepared using the recently described N-pent-4-enoyl (PNT) nucleoside phosphoramidates and H-phosphonates. Biophysical properties and stability studies suggest that these MBOs are novel antisense molecules.
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收藏
页码：1491 / 1495
页数：5
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