RETRACTED: Enantioselective Organocatalytic Hantzsch Synthesis of Polyhydroquinolines (Retracted article. See vol. 23, pg. 3802, 2021)

被引：125
|
作者：
Evans, Christopher G.
Gestwicki, Jason E. [1 ]
机构：
[1] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 14期
关键词：
ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; EFFICIENT ONE-POT; MULTICOMPONENT REACTIONS; TRANSFER HYDROGENATION; 3-COMPONENT SYNTHESIS; BIGINELLI REACTION; MANNICH REACTIONS; DERIVATIVES; GENERATION;
D O I：
10.1021/ol901114f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The four-component Hantzsch reaction provides access to pharmaceutically important dihydropyridines. To expand the utility of this method, we have developed a route under organocatalytic conditions with good yields and excellent ee's. Through catalyst screening, we found that a BINOL-phosphoric acid allowed enantioselective synthesis of six-membered heterocycles with a variety of substitution patterns.
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页码：2957 / 2959
页数：3
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