Spiroisoxazoline synthesis via intramolecular cyclization/methylation

被引：9

作者：

Xu, Jianping ^{[1
]}

Wang, Jun ^{[1
]}

Ellis, Erick D. ^{[1
]}

Hamme, Ashton T., II ^{[1
]}

机构：

[1] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA

来源：

SYNTHESIS-STUTTGART | 2006年 / 22卷 / 22期

关键词：

spiro compounds; regioselectivity; cycloadditions; ring closure; heterocycles;

D O I：

10.1055/s-2006-950302

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of regioisomeric spiroisoxazolines was achieved through an intramolecular cyclization/methylation reaction of a functionalized 5,5 -disubstituted isoxazoline in one reaction vessel. The 5,5-isoxazoline was constructed through a 1,3-dipolar cycloaddition reaction of an aromatic nitrile oxide and a geminal disubstituted alkene.

引用

页码：3815 / 3818

页数：4

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