Synthesis of (±)-oleocanthal via a tandem intramolecular Michael cyclization-HWE olefination

被引：26
|
作者：
English, Brandon J. [1 ]
Williams, Robert M. [1 ,2 ]
机构：
[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA
[2] Univ Colorado, Ctr Canc, Aurora, CO 80045 USA
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 23期
基金：
美国国家卫生研究院;
关键词：
ALPHA PRODUCTION; IRIDOIDS; INHIBITION; POTENT;
D O I：
10.1016/j.tetlet.2009.03.145
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A synthesis of racemic oleocanthal has been accomplished in 11 steps from 1,3 propanediol by a key tandem intramolecular Michael cyclization-Horner-Wadsworth-Emmons olefination. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2713 / 2715
页数：3
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