Triterpenoids from Picrasma quassioides with their cytotoxic activities

被引：11
|
作者：
Bai, Ming [1 ]
Zhao, Wen-Yu [1 ]
Xu, Wei [1 ]
Zhang, Yang-Yang [1 ]
Huang, Xiao-Xiao [1 ]
Song, Shao-Jiang [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Key Lab Computat Chem Based Nat Antitumor Drug Re, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2020年 / 39卷
关键词：
Picrasma quassioides; Triterpenoids; Structure elucidation; Cytotoxicity; TIRUCALLANE-TYPE TRITERPENOIDS;
D O I：
10.1016/j.phytol.2020.07.014
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eleven triterpenoids, including a new tirucallane-type triterpenoid and a new natural product, were isolated from Picrasma quassioides. Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated for their cytotoxic activities against Hep3B and HepG2 cell lines. Compounds 1 and 4 showed moderate cytotoxic activities toward the HepG2 cell at 50 mu M, and 1 and 4 displayed equivalent effect to the positive control on Hep3B cell.
引用
收藏
页码：128 / 131
页数：4
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