Triterpenoids from Picrasma quassioides with their cytotoxic activities

被引：11
|
作者：
Bai, Ming [1 ]
Zhao, Wen-Yu [1 ]
Xu, Wei [1 ]
Zhang, Yang-Yang [1 ]
Huang, Xiao-Xiao [1 ]
Song, Shao-Jiang [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Key Lab Computat Chem Based Nat Antitumor Drug Re, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2020年 / 39卷
关键词：
Picrasma quassioides; Triterpenoids; Structure elucidation; Cytotoxicity; TIRUCALLANE-TYPE TRITERPENOIDS;
D O I：
10.1016/j.phytol.2020.07.014
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eleven triterpenoids, including a new tirucallane-type triterpenoid and a new natural product, were isolated from Picrasma quassioides. Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated for their cytotoxic activities against Hep3B and HepG2 cell lines. Compounds 1 and 4 showed moderate cytotoxic activities toward the HepG2 cell at 50 mu M, and 1 and 4 displayed equivalent effect to the positive control on Hep3B cell.
引用
收藏
页码：128 / 131
页数：4
相关论文
共 50 条
  • [31] Anti-inflammatory Alkaloids from the Stems of Picrasma quassioides BENNET
    Jiao, Wei-Hua
    Gao, Hao
    Zhao, Feng
    Lin, Hou-Wen
    Pan, Yu-Min
    Zhou, Guang-Xiong
    Yao, Xin-Sheng
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (03) : 359 - 364
  • [32] ?-carboline alkaloids in Picrasma quassioides and their chemotaxonomic significance
    Han, Jin-Ling
    Lv, Tian-Ming
    Song, Shao-Jiang
    Huang, Xiao-Xiao
    BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2023, 107
  • [33] A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides
    ZHANG Jie
    WANG Chuan-Xi
    SONG Xiao-Jun
    LI Shuang
    ZHAO Huan
    CHEN Guo-Dong
    HU Dan
    GAO Hao
    YAO Xin-Sheng
    Chinese Journal of Natural Medicines, 2019, 17 (12) : 906 - 911
  • [34] A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides
    Zhang Jie
    Wang Chuan-Xi
    Song Xiao-Jun
    Li Shuang
    Zhao Huan
    Chen Guo-Dong
    Hu Dan
    Gao Hao
    Yao Xin-Sheng
    CHINESE JOURNAL OF NATURAL MEDICINES, 2019, 17 (12) : 906 - 911
  • [35] Tobacco Mosaic Virus (TMV) Inhibitors from Picrasma quassioides Benn
    Chen, Jia
    Yan, Xiao-Hui
    Dong, Jia-Hong
    Sang, Peng
    Fang, Xin
    Di, Ying-Tong
    Zhang, Zhong-Kai
    Hao, Xiao-Jiang
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2009, 57 (15) : 6590 - 6595
  • [36] A New Neolignan and a New Sesterterpenoid from the Stems of Picrasma quassioides BENNET
    Jiao, Wei-Hua
    Gao, Hao
    Zhao, Feng
    He, Fei
    Zhou, Guang-Xiong
    Yao, Xin-Sheng
    CHEMISTRY & BIODIVERSITY, 2011, 8 (06) : 1163 - 1169
  • [37] PHENYLPROPANOIDS AND OTHER SECONDARY METABOLITES FROM FRESH FRUITS OF PICRASMA QUASSIOIDES
    YOSHIKAWA, K
    SUGAWARA, S
    ARIHARA, S
    PHYTOCHEMISTRY, 1995, 40 (01) : 253 - 256
  • [38] Inhibition of CYP450 enzymes by quassinoids from Picrasma quassioides leaves
    Liu, Chang
    Chen, Rong-Rong
    Yang, Li
    Song, Zhong-Chen
    Wang, Zheng-Tao
    PHYTOCHEMISTRY LETTERS, 2019, 30 : 138 - 142
  • [39] N-methoxy-β-carboline alkaloids with inhibitory activities against Aβ42 aggregation and acetylcholinesterase from the stems of Picrasma quassioides
    Zhang, Jie
    Zhao, Sen-Sen
    Xie, Jun
    Yang, Jian
    Chen, Guo-Dong
    Hu, Dan
    Zhang, Wei-Guang
    Wang, Chuan-Xi
    Yao, Xin-Sheng
    Gao, Hao
    BIOORGANIC CHEMISTRY, 2020, 101
  • [40] STEREOSTRUCTURE OF PICRASIN-A, SIMAROUBOLIDE OF PICRASMA-QUASSIOIDES
    HIKINO, H
    OHTA, T
    TAKEMOTO, T
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1970, 18 (05) : 1082 - +
12345