Triterpenoids from Picrasma quassioides with their cytotoxic activities

被引：11
|
作者：
Bai, Ming [1 ]
Zhao, Wen-Yu [1 ]
Xu, Wei [1 ]
Zhang, Yang-Yang [1 ]
Huang, Xiao-Xiao [1 ]
Song, Shao-Jiang [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Key Lab Computat Chem Based Nat Antitumor Drug Re, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2020年 / 39卷
关键词：
Picrasma quassioides; Triterpenoids; Structure elucidation; Cytotoxicity; TIRUCALLANE-TYPE TRITERPENOIDS;
D O I：
10.1016/j.phytol.2020.07.014
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Eleven triterpenoids, including a new tirucallane-type triterpenoid and a new natural product, were isolated from Picrasma quassioides. Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated for their cytotoxic activities against Hep3B and HepG2 cell lines. Compounds 1 and 4 showed moderate cytotoxic activities toward the HepG2 cell at 50 mu M, and 1 and 4 displayed equivalent effect to the positive control on Hep3B cell.
引用
收藏
页码：128 / 131
页数：4
相关论文
共 50 条
  • [1] Cytotoxic Tirucallane and Apotirucallane Triterpenoids from the Stems of Picrasma quassioides
    Xu, Jian
    Xiao, Di
    Lin, Qing-Hua
    He, Jing-Feng
    Liu, Wen-Yuan
    Xie, Ning
    Feng, Feng
    Qu, Wei
    JOURNAL OF NATURAL PRODUCTS, 2016, 79 (08): : 1899 - 1910
  • [2] Seven Alkaloids from Picrasma quassioides and Their Cytotoxic Activities
    Zheng-Quan Lai
    Wei-Hai Liu
    Siu-Po Ip
    Hui-Jun Liao
    Yu-Yang Yi
    Zhen Qin
    Xiao-Ping Lai
    Zi-Ren Su
    Zhi-Xiu Lin
    Chemistry of Natural Compounds, 2014, 50 : 884 - 888
  • [3] Seven Alkaloids from Picrasma quassioides and Their Cytotoxic Activities
    Lai, Zheng-Quan
    Liu, Wei-Hai
    Ip, Siu-Po
    Liao, Hui-Jun
    Yi, Yu-Yang
    Qin, Zhen
    Lai, Xiao-Ping
    Su, Zi-Ren
    Lin, Zhi-Xiu
    CHEMISTRY OF NATURAL COMPOUNDS, 2014, 50 (05) : 884 - 888
  • [4] Cytotoxic alkaloids from the wood of Picrasma quassioides
    Jeong Joo Lee
    Chan-Ho Oh
    Jae Heon Yang
    Nam-In Baek
    Sung-Hoon Kim
    Chong Hyeon Cho
    Dae Keun Kim
    Journal of the Korean Society for Applied Biological Chemistry, 2009, 52 : 663 - 667
  • [5] New tirucallane triterpenoids from Picrasma quassioides with their potential antiproliferative activities on hepatoma cells
    Zhao, Wen-Yu
    Chen, Jing-Jie
    Zou, Chun-Xin
    Zhang, Ying-Ying
    Yao, Guo-Dong
    Wang, Xiao-Bo
    Huang, Xiao-Xiao
    Lin, Bin
    Song, Shao-Jiang
    BIOORGANIC CHEMISTRY, 2019, 84 : 309 - 318
  • [6] Cytotoxic Alkaloids from the Wood of Picrasma quassioides
    Lee, Jeong Joo
    Oh, Chan-Ho
    Yang, Jae Heon
    Baek, Nam-In
    Kim, Sung-Hoon
    Cho, Chong Hyeon
    Kim, Dae Keun
    JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, 2009, 52 (06): : 663 - 667
  • [7] Quassinoids from the stems of Picrasma quassioides and their cytotoxic and NO production-inhibitory activities
    Xu, Jian
    Xiao, Di
    Song, Wei-Wu
    Chen, Lei
    Liu, Wen-Yuan
    Xie, Ning
    Feng, Feng
    Qu, Wei
    FITOTERAPIA, 2016, 110 : 13 - 19
  • [8] Biological Activities of Fractions from Methanolic Extract of Picrasma quassioides
    Yu Yin
    Seong-Il Heo
    Kwang Soo Roh
    Myeong-Hyeon Wang
    Journal of Plant Biology, 2009, 52 : 325 - 331
  • [9] Biological Activities of Fractions from Methanolic Extract of Picrasma quassioides
    Yin, Yu
    Heo, Seong-Il
    Roh, Kwang Soo
    Wang, Myeong-Hyeon
    JOURNAL OF PLANT BIOLOGY, 2009, 52 (04) : 325 - 331
  • [10] Aromatic glycosides and lignans glycosides with their acetylcholinesterase inhibitory activities from the leaves of Picrasma quassioides
    Jia, Qi
    Yang, Pei -Yuan
    Zhang, Xin
    Song, Shao-Jiang
    Huang, Xiao-Xiao
    FITOTERAPIA, 2024, 172
12345