Improving ICI outcomes with a little help from my microbial friends

被引：2

作者：

Rebeck, Olivia N. ^{[1
]}

Dantas, Gautam ^{[1
,2
,3
,4
]}

Schwartz, Drew J. ^{[1
,5
]}

机构：

[1] Washington Univ, Sch Med, Edison Family Ctr Genome Sci & Syst Biol, St Louis, MO 63130 USA

[2] Washington Univ, Sch Med, Dept Mol Microbiol & Microbial Pathogenesis, St Louis, MO USA

[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[4] Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA

[5] Washington Univ, Sch Med, Dept Pediat, Div Infect Dis, St Louis, MO 63110 USA

来源：

CELL HOST & MICROBE | 2021年 / 29卷 / 02期

关键词：

D O I：

10.1016/j.chom.2021.01.012

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Gut microbiome composition correlates with responsiveness to immune checkpoint inhibitor therapy. In a recent study in Science, Baruch et al. manipulated gut microbiome composition in patients with refractory metastatic melanoma using fecal microbiota transplants. Fecal microbiota transplant was safe and partially effective in inducing remission in refractory patients.

引用

页码：155 / 157

页数：3

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