Pathological and clinical correlations in renal AA amyloidosis: A Moroccan series of 30 cases

被引：3

作者：

Bziz, Asmae ^{[1
]}

Rouas, Lamia ^{[1
]}

Lamalmi, Najat ^{[1
]}

Malihy, Abderrahmane ^{[1
]}

Cherradi, Nadia ^{[1
]}

Ouzeddoun, Naima ^{[2
]}

Bayahia, Rabia ^{[2
]}

Flayou, Kaoutar ^{[2
]}

Chala, Sanae ^{[3
]}

Bouclouze, Aziz ^{[4
]}

Benomar, Ali ^{[5
]}

Abougal, Redouan ^{[3
]}

Alhamany, Zaitouna ^{[1
]}

机构：

[1] Univ Mohammed 5, Hop Enfants, Fac Med & Pharm, Lab Anat Cytol Pathol, Rabat, Morocco

[2] Univ Mohammed 5, Hop Ibn Sina Avicenne, Fac Med & Pharm, Serv Nephrol, Rabat, Morocco

[3] Univ Mohammed 5, Fac Med & Pharm, LBRCE, Rabat, Morocco

[4] Univ Mohammed 5, Fac Med & Pharm, Plateau Tech & Rech, Rabat, Morocco

[5] Fac Med & Pharm, Ctr Rech Clin Epidemiol & Essais Therapeut CRECET, Rabat, Morocco

来源：

NEPHROLOGIE & THERAPEUTIQUE | 2015年 / 11卷 / 07期

关键词：

AA amyloidosis; Amyloid deposit; Chronic infections; CASTLEMANS-DISEASE; CLASSIFICATION; PATHOGENESIS; SYSTEM;

D O I：

10.1016/j.nephro.2015.06.007

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. - Study of histological and clinical correlations of 30 cases of renal amyloidosis AA diagnosed between November 2010 and December 2012. Results. - The main causes associated with amyloidosis AA were represented by chronic infectious diseases (60%). Nephrotic syndrome and renal failure were observed in 94% and 73% respectively. The distribution of amyloid deposits: 90% of patients had a glomerular form and 10% had a vascular form. Inflammatory reaction associated with AA renal amyloidosis was present in 50% of cases. This inflammation was observed near amyloid deposits associated with a deposition of immunoglobulin chains and/or complement factors. Conclusion. - Our study confirms the predominance of AA amyloidosis complicating chronic infectious diseases, especially tuberculosis. Our data point out a relationship between the morphology of renal AA amyloidosis, its clinical presentation and prognosis. (C) 2015 Association Societe de nephrologie. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：543 / 550

页数：8

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