Pathological and clinical correlations in renal AA amyloidosis: A Moroccan series of 30 cases

被引：3
|
作者：
Bziz, Asmae [1 ]
Rouas, Lamia [1 ]
Lamalmi, Najat [1 ]
Malihy, Abderrahmane [1 ]
Cherradi, Nadia [1 ]
Ouzeddoun, Naima [2 ]
Bayahia, Rabia [2 ]
Flayou, Kaoutar [2 ]
Chala, Sanae [3 ]
Bouclouze, Aziz [4 ]
Benomar, Ali [5 ]
Abougal, Redouan [3 ]
Alhamany, Zaitouna [1 ]
机构：
[1] Univ Mohammed 5, Hop Enfants, Fac Med & Pharm, Lab Anat Cytol Pathol, Rabat, Morocco
[2] Univ Mohammed 5, Hop Ibn Sina Avicenne, Fac Med & Pharm, Serv Nephrol, Rabat, Morocco
[3] Univ Mohammed 5, Fac Med & Pharm, LBRCE, Rabat, Morocco
[4] Univ Mohammed 5, Fac Med & Pharm, Plateau Tech & Rech, Rabat, Morocco
[5] Fac Med & Pharm, Ctr Rech Clin Epidemiol & Essais Therapeut CRECET, Rabat, Morocco
来源：
NEPHROLOGIE & THERAPEUTIQUE | 2015年 / 11卷 / 07期
关键词：
AA amyloidosis; Amyloid deposit; Chronic infections; CASTLEMANS-DISEASE; CLASSIFICATION; PATHOGENESIS; SYSTEM;
D O I：
10.1016/j.nephro.2015.06.007
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Objective. - Study of histological and clinical correlations of 30 cases of renal amyloidosis AA diagnosed between November 2010 and December 2012. Results. - The main causes associated with amyloidosis AA were represented by chronic infectious diseases (60%). Nephrotic syndrome and renal failure were observed in 94% and 73% respectively. The distribution of amyloid deposits: 90% of patients had a glomerular form and 10% had a vascular form. Inflammatory reaction associated with AA renal amyloidosis was present in 50% of cases. This inflammation was observed near amyloid deposits associated with a deposition of immunoglobulin chains and/or complement factors. Conclusion. - Our study confirms the predominance of AA amyloidosis complicating chronic infectious diseases, especially tuberculosis. Our data point out a relationship between the morphology of renal AA amyloidosis, its clinical presentation and prognosis. (C) 2015 Association Societe de nephrologie. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：543 / 550
页数：8
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