Catalytic Enantioselective Aldol Additions to Ketones

被引：55

作者：

Adachi, Shinya ^{[1
]}

Harada, Toshiro ^{[1
]}

机构：

[1] Kyoto Inst Technol, Dept Chem & Mat Technol, Sakyo Ku, Kyoto 6068585, Japan

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 22期

关键词：

Aldol reactions; Asymmetric catalysis; Asymmetric synthesis; Ketones; C-2-SYMMETRIC COPPER(II) COMPLEXES; QUATERNARY CARBON CENTERS; CHIRAL LEWIS-ACIDS; C BOND FORMATION; REDUCTIVE ALDOL; ASYMMETRIC ALDOL; REFORMATSKY REACTION; CONJUGATE REDUCTION; MICHAEL ADDITION; ACYCLIC ENONES;

D O I：

10.1002/ejoc.200900166

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective aldol addition to ketones has received growing attention since the resulting tertiary aldols are valuable building blocks for many biologically active compounds. Recently, several catalytic methodologies have been developed based on the activation of acceptor ketones and/or nucleophile enolates, overcoming problems associated with the lower reactivity and decreased steric discrimination of ketones compared to aldehydes. This microreview presents an overview of the progresses in the catalytic enantioselective aldol additions to ketones. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

引用

页码：3661 / 3671

页数：11

共 50 条

[41] Catalytic Diastereo- and Enantioselective Synthesis of TertiaryTrifluoromethyl Carbinols through a Vinylogous Aldol Reaction ofAlkylidenepyrazolones with Trifluoromethyl Ketones
Carceller-Ferrer, Laura
Gonzalez del Campo, Aleix
Vila, Carlos
Blay, Gonzalo
Carmen Munoz, M.
Pedro, Jose R.
JOURNAL OF ORGANIC CHEMISTRY, 2022, 87 (07): : 4538 - 4549
[42] Organocatalytic Enantioselective Vinylogous Aldol Reaction of Allyl Aryl Ketones to Activated Acyclic Ketones
Jing, Zhenzhong
Bai, Xiangbin
Chen, Wenchao
Zhang, Gao
Zhu, Bo
Jiang, Zhiyong
ORGANIC LETTERS, 2016, 18 (02) : 260 - 263
[43] Catalytic enantioselective conjugate additions with α,β-unsaturated sulfones
Li, Hongming
Song, Jun
Deng, Li
TETRAHEDRON, 2009, 65 (16) : 3139 - 3148
[44] Highly enantioselective catalytic conjugate additions to cyclohexadienones
Imbos, R
Brilman, MHG
Pineschi, M
Feringa, BL
ORGANIC LETTERS, 1999, 1 (04) : 623 - 625
[45] Recent advances in catalytic enantioselective Michael additions
Krause, N
Hoffmann-Röder, A
SYNTHESIS-STUTTGART, 2001, (02): : 171 - 196
[46] CATALYTIC, ENANTIOSELECTIVE ACETATE ALDOL ADDITION-REACTIONS
CARREIRA, EM
SINGER, RA
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 209 : 191 - ORGN
[47] Enantioselective Cross-Aldol Reaction with Ketones and Non-Enolizable Ketones Catalyzed by Tetrapeptides
Wang, Pei
Zhang, Yang
Yang, Hong
Ma, Guo-Rong
Wang, Jin-Bao
Yang, Wen
Du, Zhi-Hong
Da, Chao-Shan
CHEMISTRYSELECT, 2021, 6 (30): : 7722 - 7726
[48] Proline catalyzed enantioselective Michael additions of unmodified ketones to arylidines
Moirangthem, Nimalini
Thingom, Bhavna
Moirangthem, Soniya D.
Laitonjam, Warjeet S.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2013, 52 (07): : 937 - 941
[49] Proline-catalyzed enantioselective Michael additions of ketones to nitrostyrene
Enders, D
Seki, A
SYNLETT, 2002, (01) : 26 - 28
[50] Enantioselective and Diastereoselective Conjugate Radical Additions to -Arylidene Ketones and Lactones
Zhao, Changjia
Sibi, Mukund P.
SYNLETT, 2017, 28 (20) : 2971 - 2975

← 1 2 3 4 5 →