PF1092A, B and C, new nonsteroidal progesterone receptor ligands produced by Penicillium oblatum .2. Physico-chemical properties and structure elucidation

被引：17
|
作者：
Tabata, Y
Hatsu, M
Kurata, Y
Miyajima, K
Tani, M
Sasaki, T
Kodama, Y
Tsuruoka, T
Omoto, S
机构：
[1] Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Kohoku-ku, Yokohama 222
[2] Department of Biotechnology, Faculty of Agriculture, Gifu University, Gifu 501-11
来源：
JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 04期
关键词：
D O I：
10.7164/antibiotics.50.309
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The structures of PF1092A (1), B (2) and C (3), new nonsteroidal progesterone receptor ligands produced by Penicillium oblatum, were elucidated by spectroscopic analyses. These compounds possess an eremophilane-type sesquiterpene carbon skeleton and differ only in that 1 and 2 are different monoacetates of 3. The absolute configurations of 1 similar to 3 were determined by single crystal X-ray diffraction analysis of the 4-bromobenzoyl ester of PF1092A and by measuring the optical rotations of the acetylation products of these compounds.
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页码：309 / 313
页数：5
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