Tucupentol, a Novel Mono-tetrahydrofuranic Acetogenin from Annona montana, as a Potent Inhibitor of Mitochondrial Complex I

被引：15

作者：

Alvarez Colom, Olga ^{[1
]}

Neske, Adriana ^{[1
]}

Chahboune, Nadia ^{[2
]}

Carmen Zafra-Polo, M. ^{[2
]}

Bardon, Alicia ^{[1
]}

机构：

[1] Univ Nacl Tucumin, Inst Quim Organ, Fac Bioquim Quim & Farm, San Miguel De Tucuman, Argentina

[2] Univ Valencia, Dept Farmacol, Fac Farm, E-46100 Burjassot, Spain

来源：

CHEMISTRY & BIODIVERSITY | 2009年 / 6卷 / 03期

关键词：

RING ACETOGENINS; MURICATA; LEAVES;

D O I：

10.1002/cbdv.200800102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ten acetogenins, one of them new, were isolated from leaves and twigs of a Bolivian collection of Annona montana. The new compound that we named tucupentol (1) is a mono-tetrahydrofuran-pentahydroxy-acetogenin. The inhibitory potency of tucupentol (1) on the mitochondrial complex I was evaluated, and this activity was compared with that of the known acetogenins, annonacin-A, cis-annonacin-10-one, aromin, and gigantetronenin, also isolated from this plant material. The mentioned acetogenins acted as selective inhibitors of mitochondrial complex I in the 0.8-5.4-nM range.

引用

页码：335 / 340

页数：6

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