Mitochondrial complex I: new insights from inhibitor assays

被引：9
|
作者：
Estornell, E [1 ]
机构：
[1] Univ Valencia, Fac Farm, Dept Bioquim & Biol Mol, E-46100 Burjassot, Spain
来源：
PROTOPLASMA | 2000年 / 213卷 / 1-2期
关键词：
NADH : ubiquinone oxidoreductase; mitochondrial complex I; respiratory inhibitor; acetogenin; mitochondrial respiratory chain;
D O I：
10.1007/BF01280500
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The NADH:ubiquinone oxidoreductase (complex I) of the mitochondrial respiratory chain is by ar the most complicated of the proton-translocating enzymes involved in the oxidative phosphorylation. Many clues regarding both electron transfer and proton translocation are still unknown. In this sense, inhibitor assays are relevant and useful pieces for elaborating a suitable model to explain the elusive bioenergetic mechanism of this enzyme. This short review presents the most recent advances in inhibitor studies and highlights the major controversies.
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收藏
页码：11 / 17
页数：7
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