Tucupentol, a Novel Mono-tetrahydrofuranic Acetogenin from Annona montana, as a Potent Inhibitor of Mitochondrial Complex I

被引：15
|
作者：
Alvarez Colom, Olga [1 ]
Neske, Adriana [1 ]
Chahboune, Nadia [2 ]
Carmen Zafra-Polo, M. [2 ]
Bardon, Alicia [1 ]
机构：
[1] Univ Nacl Tucumin, Inst Quim Organ, Fac Bioquim Quim & Farm, San Miguel De Tucuman, Argentina
[2] Univ Valencia, Dept Farmacol, Fac Farm, E-46100 Burjassot, Spain
来源：
CHEMISTRY & BIODIVERSITY | 2009年 / 6卷 / 03期
关键词：
RING ACETOGENINS; MURICATA; LEAVES;
D O I：
10.1002/cbdv.200800102
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ten acetogenins, one of them new, were isolated from leaves and twigs of a Bolivian collection of Annona montana. The new compound that we named tucupentol (1) is a mono-tetrahydrofuran-pentahydroxy-acetogenin. The inhibitory potency of tucupentol (1) on the mitochondrial complex I was evaluated, and this activity was compared with that of the known acetogenins, annonacin-A, cis-annonacin-10-one, aromin, and gigantetronenin, also isolated from this plant material. The mentioned acetogenins acted as selective inhibitors of mitochondrial complex I in the 0.8-5.4-nM range.
引用
收藏
页码：335 / 340
页数：6
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