Rollimembrin, a novel acetogenin inhibitor of mammalian mitochondrial complex I

被引：0
|
作者：
Gonzalez, MC
Tormo, JR
Bermejo, A
ZafraPolo, MC
Estornell, E
Cortes, D
机构：
[1] UNIV VALENCIA, FAC FARM, DEPT FARMACOL FARMACOGNOSIA & FARMACODINAMIA, E-46100 BURJASSOT, VALENCIA, SPAIN
[2] UNIV VALENCIA, FAC FARM, DEPT BIOQUIM & BIOL MOL, E-46100 BURJASSOT, VALENCIA, SPAIN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 09期
关键词：
D O I：
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Rollimembrin (3), is a new adjacent bis-tetrahydrofuranic acetogenin with a scarce relative configuration, threo/cis/threo/cis/eryyhro, isolated from Rollinia membranacea seeds. The mechanism of cytotoxic activity, determined by NADH-oxidase experiments, establish that rollimembrin (3) is the most potent inhibitor of mammalian mitochondrial complex I. (C) 1997 Elsevier Science Ltd.
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页码：1113 / 1118
页数：6
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