Reduction of the Wnt inhibitor Dkk1 increases bone density in mice

被引:0
|
作者
MacDonald, Bryan T.
Sharma, Parul
Patntirapong, Somying
Oyserman, Sivan M.
Samuel, Raymond E.
He, Xi
Goldstein, A.
Hauschka, Peter V.
机构
[1] Harvard Univ, Sch Med, Childrens Hosp, Div Neurosci, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Childrens Hosp, Dept Orthopaed Surg, Boston, MA 02115 USA
[3] Univ Michigan, Orthopaed Res Labs, Dept Orthopaed Surg, Ann Arbor, MI 48109 USA
关键词
D O I
10.1016/j.ydbio.2006.04.087
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
70
引用
收藏
页码:353 / 353
页数:1
相关论文
共 50 条
  • [41] Serum DKK1 is associated with bone lesions in MM patients
    Fisac-Herrero, R. M.
    Hernandez-Martin, J. M.
    Olivier, C.
    Queizan, J. A.
    Cuello, R.
    Barez, A.
    Martin, A.
    Garcia-Sanz, R.
    Garcia-Frade, F. J.
    Aguilera, C.
    Martin-Nunez, G.
    Casado-Garcia, T. M.
    San Miguel, J. F.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 (06): : 129 - 129
  • [42] On the Role of DKK1 in Diseases of the Bone: Multiple Myeloma as the Prototype
    Shaughnessy, J. D., Jr.
    Qiang, Y.
    Yaccoby, S.
    Barlogie, B.
    BONE, 2010, 47 : S281 - S281
  • [43] Dkk-1 inhibition increases bone mineral density in rodents.
    Grisanti, M.
    Niu, Q. T.
    Fan, W.
    Asuncion, F.
    Lee, J.
    Steavenson, S.
    Chen, Q.
    Li, J.
    Geng, Z.
    Kostenuik, P.
    Lacey, D. L.
    Simonet, W. S.
    Ominsky, M.
    Li, X.
    Richards, W. G.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 : S25 - S25
  • [44] Epigenetic silencing of the WNT antagonist dickkopf-1(DKK1) in multiple myeloma
    Kocemba, K. A.
    Groen, R. W.
    Kersten, M. J.
    Bloem, A. C.
    Lokhorst, H. M.
    Spaargaren, M.
    Pals, S. T.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 (06): : 117 - 117
  • [45] Dkk1 and Wnt3 interact to control head morphogenesis in the mouse
    Lewis, Samara L.
    Khoo, Poh-Lynn
    De Young, R. Andrea
    Steiner, Kirsten
    Wilcock, Chris
    Mukhopadhyay, Mahua
    Westphal, Heiner
    Jamieson, Robyn V.
    Robb, Lorraine
    Tam, Patrick P. L.
    DEVELOPMENT, 2008, 135 (10): : 1791 - 1801
  • [46] Dkk1 and Wnt3 interaction is critical for head morphogenesis in the mouse
    Tam, Patrick P.
    Lewis, Samara L.
    Khoo, Poh-Lynn
    De Young, R. Andrea
    Westphal, Heiner
    DEVELOPMENTAL BIOLOGY, 2007, 306 (01) : 401 - 401
  • [47] Anti-Sost/Dkk1 Antibody Therapy Increases Bone Formation in Old Mice, but Does Not Enhance Their Modest Response to Tibial Loading
    Lawson, Lisa
    Brodt, Michael
    Silva, Matthew
    JOURNAL OF BONE AND MINERAL RESEARCH, 2018, 33 : 83 - 83
  • [48] Identification of XD23 as a potent inhibitor of osteosarcoma via downregulation of DKK1 and activation of the WNT/β-catenin pathway
    Xie, Qian
    Shen, Yanni
    Yang, Yipei
    Liang, Jianhui
    Wu, Tailin
    Hu, Chun
    Wang, Yan
    Tao, Huiren
    ISCIENCE, 2024, 27 (09)
  • [49] DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway
    Niida, A
    Hiroko, T
    Kasai, M
    Furukawa, Y
    Nakamura, Y
    Suzuki, Y
    Sugano, S
    Akiyama, T
    ONCOGENE, 2004, 23 (52) : 8520 - 8526
  • [50] The Wnt Antagonist Dkk1 Regulates Intestinal Epithelial Homeostasis and Wound Repair
    Koch, Stefan
    Nava, Porfirio
    Addis, Caroline
    Kim, Wooki
    Denning, Timothy L.
    Li, Linheng
    Parkos, Charles A.
    Nusrat, Asma
    GASTROENTEROLOGY, 2011, 141 (01) : 259 - U354