DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway

被引：447

作者：

Niida, A

Hiroko, T

Kasai, M

Furukawa, Y

Nakamura, Y

Suzuki, Y

Sugano, S

Akiyama, T

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Lab Mol & Genet Informat, Bunkyo Ku, Tokyo 1130032, Japan

[2] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab,Minato Ku, Tokyo 1088639, Japan

[3] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Database,Minato Ku, Tokyo 1088639, Japan

来源：

ONCOGENE | 2004年 / 23卷 / 52期

关键词：

DKK1; Wnt; beta-catenin; TCF; TCF-binding element; negative feedback;

D O I：

10.1038/sj.onc.1207892

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the beta-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. TCF-binding elements have been found in the promoter regions of many TCF target genes and characterized by a highly conserved consensus sequence. Utilizing this consensus sequence, we performed an in silico screening for new TCF target genes. Through computational screening and subsequent experimental analysis, we identified a novel TCF target gene, DKK1, which has been shown to be a potent inhibitor of Wnt signaling. Our finding suggests the existence of a novel feedback loop in Wnt signaling.

引用

页码：8520 / 8526

页数：7

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