Protein motions promote catalysis

被引：99

作者：

Tousignant, A ^{[1
]}

Pelletier, JN ^{[1
]}

机构：

[1] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada

来源：

CHEMISTRY & BIOLOGY | 2004年 / 11卷 / 08期

关键词：

D O I：

10.1016/j.chembiol.2004.06.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A relationship between molecular dynamics motions of noncatalytic residues and enzyme activity has recently been proposed. We present examples where mutations either near or distal from the active site residues modify internal enzyme motion with resulting modification of catalysis. A better understanding of internal protein motions correlated to catalysis will lead to a greater insight into enzyme function.

引用

页码：1037 / 1042

页数：6

共 50 条

[31] The Secret Ultrafast Motions of Protein Nanomachines
Haran, Gilad
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2023, 52 (SUPPL 1): : S44 - S44
[32] Simulating protein motions with rigidity analysis
Thomas, Shawna
Tang, Xinyu
Tapia, Lydia
Amato, Nancy M.
RESEARCH IN COMPUTATIONAL MOLECULAR BIOLOGY, PROCEEDINGS, 2006, 3909 : 394 - 409
[33] Models To Approximate the Motions of Protein Loops
Skliros, Aris
Jernigan, Robert L.
Kloczkowski, Andrzej
JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2010, 6 (10) : 3249 - 3258
[34] Concerted motions in the photoactive yellow protein
van Aalten, DMF
Hoff, WD
Findlay, JBC
Crielaard, W
Hellingwerf, KJ
PROTEIN ENGINEERING, 1998, 11 (10): : 873 - 879
[35] Protein folding is slaved to solvent motions
Frauenfelder, H.
Fenimore, P. W.
Chen, G.
McMahon, B. H.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (42) : 15469 - 15472
[36] Hierarchy of fast motions in protein dynamics
Mazur, AK
JOURNAL OF PHYSICAL CHEMISTRY B, 1998, 102 (02): : 473 - 479
[37] HELIX DYNAMICS AND PROTEIN LOOP MOTIONS
ANDERSEN, NH
HARRIS, SM
CHEN, CP
CAO, BL
JOURNAL OF CELLULAR BIOCHEMISTRY, 1993, : 289 - 289
[38] Algorithm for backrub motions in protein design
Georgiev, Ivelin
Keedy, Daniel
Richardson, Jane S.
Richardson, David C.
Donald, Bruce R.
BIOINFORMATICS, 2008, 24 (13) : I196 - I204
[39] Correlated Motions from Protein Crystallography
Meisburger, Steve P.
Case, David A.
Ando, Nozomi
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2018, 74 : A70 - A70
[40] Simulating protein motions with rigidity analysis
Thomas, Shawna
Tang, Xinyu
Tapia, Lydia
Amato, Nancy M.
JOURNAL OF COMPUTATIONAL BIOLOGY, 2007, 14 (06) : 839 - 855

← 1 2 3 4 5 →