Protein motions promote catalysis

被引：99

作者：

Tousignant, A ^{[1
]}

Pelletier, JN ^{[1
]}

机构：

[1] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada

来源：

CHEMISTRY & BIOLOGY | 2004年 / 11卷 / 08期

关键词：

D O I：

10.1016/j.chembiol.2004.06.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A relationship between molecular dynamics motions of noncatalytic residues and enzyme activity has recently been proposed. We present examples where mutations either near or distal from the active site residues modify internal enzyme motion with resulting modification of catalysis. A better understanding of internal protein motions correlated to catalysis will lead to a greater insight into enzyme function.

引用

页码：1037 / 1042

页数：6

共 50 条

[21] Anticorrelated motions as a driving force in enzyme catalysis: The dehydrogenase reaction
Luo, J
Bruice, TC
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (36) : 13152 - 13156
[22] The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase
Loveridge, E. Joel
Tey, Lai-Hock
Behiry, Enas M.
Dawson, William M.
Evans, Rhiannon M.
Whittaker, Sara B. -M.
Guenther, Ulrich L.
Williams, Christopher
Crump, Matthew P.
Allemann, Rudolf K.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (50) : 20561 - 20570
[23] How important are quantum mechanical nuclear motions in enzyme catalysis?
Hwang, JK
Warshel, A
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (47) : 11745 - 11751
[24] NEW LOOKS AT PROTEIN MOTIONS
FRAUENFELDER, H
NATURE, 1989, 338 (6217) : 623 - 624
[25] Domain motions in protein crystals
Moss, D
Sali, A
Slingsby, C
Simpson, A
Wostrack, A
PROTEIN STRUCTURE - FUNCTION RELATIONSHIP, 1996, : 157 - 165
[26] The chemistry of protein catalysis
Holliday, Gemma L.
Almonacid, Daniel E.
Mitchell, John B. O.
Thornton, Janet M.
JOURNAL OF MOLECULAR BIOLOGY, 2007, 372 (05) : 1261 - 1277
[27] Thermoswitchable catalysis to inhibit and promote plastic flow in vitrimers
Van Lijsebetten, Filip
Maes, Stephan
Winne, Johan M.
Du Prez, Filip E.
CHEMICAL SCIENCE, 2024, 15 (19) : 7061 - 7071
[28] Identifying Opportunities to Promote Systems Thinking in Catalysis Education
Ravi, Manoj
Puente-Urbina, Allen
van Bokhoven, Jeroen A.
JOURNAL OF CHEMICAL EDUCATION, 2021, 98 (05) : 1583 - 1593
[29] Characterizing protein motions from structure
David, Charles C.
Jacobs, Donald J.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2011, 31 : 41 - 56
[30] LOCAL AND COLLECTIVE MOTIONS IN PROTEIN DYNAMICS
KARPLUS, M
SWAMINATHAN, S
ICHIYE, T
VANGUNSTEREN, WF
CIBA FOUNDATION SYMPOSIA, 1983, 93 : 271 - 283

← 1 2 3 4 5 →