Rewarming Injury after Cold Preservation

被引:34
|
作者
Minor, Thomas [1 ]
von Horn, Charlotte [1 ]
机构
[1] Univ Hosp Essen, Dept Surg Res, Hufelandstr 55, D-45147 Essen, Germany
关键词
temperature paradox; rewarming injury; organ preservation; controlled rewarming; COR; MITOCHONDRIAL PERMEABILITY TRANSITION; NORMOTHERMIC MACHINE PERFUSION; HYPOTHERMIC OXYGENATED PERFUSION; RAT-LIVER; ORGAN PRESERVATION; REPERFUSION INJURY; KIDNEY PERFUSION; COMPLEX I; DONATION; GRAFTS;
D O I
10.3390/ijms20092059
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Organ dysfunction pertinent to tissue injury related to ischemic ex vivo preservation during transport from donor to recipient still represents a pivotal impediment in transplantation medicine. Cold storage under anoxic conditions minimizes metabolic activity, but eventually cannot prevent energetic depletion and impairment of cellular signal homeostasis. Reoxygenation of anoxically injured tissue may trigger additional damage to the graft, e.g., by abundant production of oxygen free radicals upon abrupt reactivation of a not yet equilibrated cellular metabolism. Paradoxically, this process is driven by the sudden restoration of normothermic conditions upon reperfusion and substantially less pronounced during re-oxygenation in the cold. The massive energy demand associated with normothermia is not met by the cellular systems that still suffer from hypothermic torpor and dys-equilibrated metabolites and eventually leads to mitochondrial damage, induction of apoptosis and inflammatory responses. This rewarming injury is partly alleviated by preceding supply of oxygen already in the cold but more effectively counteracted by an ensuing controlled and slow oxygenated warming up of the organ prior to implantation. A gentle restitution of metabolic turnover rates in line with the resumption of enzyme kinetics and molecular homeostasis improves post transplantation graft function and survival.
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页数:9
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