Rewarming Injury after Cold Preservation

被引:34
|
作者
Minor, Thomas [1 ]
von Horn, Charlotte [1 ]
机构
[1] Univ Hosp Essen, Dept Surg Res, Hufelandstr 55, D-45147 Essen, Germany
关键词
temperature paradox; rewarming injury; organ preservation; controlled rewarming; COR; MITOCHONDRIAL PERMEABILITY TRANSITION; NORMOTHERMIC MACHINE PERFUSION; HYPOTHERMIC OXYGENATED PERFUSION; RAT-LIVER; ORGAN PRESERVATION; REPERFUSION INJURY; KIDNEY PERFUSION; COMPLEX I; DONATION; GRAFTS;
D O I
10.3390/ijms20092059
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Organ dysfunction pertinent to tissue injury related to ischemic ex vivo preservation during transport from donor to recipient still represents a pivotal impediment in transplantation medicine. Cold storage under anoxic conditions minimizes metabolic activity, but eventually cannot prevent energetic depletion and impairment of cellular signal homeostasis. Reoxygenation of anoxically injured tissue may trigger additional damage to the graft, e.g., by abundant production of oxygen free radicals upon abrupt reactivation of a not yet equilibrated cellular metabolism. Paradoxically, this process is driven by the sudden restoration of normothermic conditions upon reperfusion and substantially less pronounced during re-oxygenation in the cold. The massive energy demand associated with normothermia is not met by the cellular systems that still suffer from hypothermic torpor and dys-equilibrated metabolites and eventually leads to mitochondrial damage, induction of apoptosis and inflammatory responses. This rewarming injury is partly alleviated by preceding supply of oxygen already in the cold but more effectively counteracted by an ensuing controlled and slow oxygenated warming up of the organ prior to implantation. A gentle restitution of metabolic turnover rates in line with the resumption of enzyme kinetics and molecular homeostasis improves post transplantation graft function and survival.
引用
收藏
页数:9
相关论文
共 50 条
  • [31] A STUDY OF VARIOUS METHODS OF REWARMING MEN AFTER EXPOSURE TO EXTREME COLD
    AMES, A
    GRIFFITH, RS
    GOLDTHWAIT, DA
    MACHT, MB
    FEDERATION PROCEEDINGS, 1948, 7 (01) : 2 - 3
  • [32] Relation between finger cold-induced vasodilation and rewarming speed after cold exposure
    C. F. Kingma
    I. I. Hofman
    H. A. M. Daanen
    European Journal of Applied Physiology, 2019, 119 : 171 - 180
  • [33] Relation between finger cold-induced vasodilation and rewarming speed after cold exposure
    Kingma, C. F.
    Hofman, I. I.
    Daanen, H. A. M.
    EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2019, 119 (01) : 171 - 180
  • [34] CYTOSKELETAL CHANGES BROUGHT ABOUT IN CULTURED SMOOTH-MUSCLE CELLS BY COLD PRESERVATION AND SUBSEQUENT REWARMING
    HALL, SM
    HAWORTH, SG
    AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 147 (04): : A139 - A139
  • [35] Unrecognized platelet physiology is the cause of rewarming deaths in accidental hypothermia and neonatal cold injury
    Cohen, Ian J.
    MEDICAL HYPOTHESES, 2021, 148
  • [36] Effect of a short period of warm ischemia after cold preservation on reperfusion injury in lung allotransplantation
    Stammberger, U
    Schmid, RA
    Hillinger, S
    Singer, T
    Schob, OM
    Zollinger, A
    Weder, W
    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 1998, 13 (04) : 442 - 447
  • [37] Kupffer cell blockade suppresses reperfusion injury after cold preservation in rat liver grafts
    Nakamura, T
    Arii, S
    Monden, K
    Adachi, Y
    Ishiguro, S
    Fujita, S
    Mizumoto, M
    Imamura, M
    CELLS OF THE HEPATIC SINUSOID, VOL 6, 1997, : 196 - 199
  • [38] Effects of cold preservation and rewarming on rat liver cell volume regulation and concentrative amino acid uptake
    Serrar, H
    Haddad, P
    GASTROENTEROLOGY, 1997, 112 (04) : 1344 - 1353
  • [39] Does melatonin alleviate cold preservation injury of the liver?
    Gunal, Omer
    Coskun, Abdurrahman
    Aslaner, Arif
    Yildirim, Umran
    TURKISH JOURNAL OF MEDICAL SCIENCES, 2010, 40 (03) : 465 - 470
  • [40] COLD PRESERVATION INJURY OF NADH-UBIQUINONE OXIDOREDUCTASE
    MENG, GY
    TANAKA, A
    TANAKA, K
    OZAWA, K
    LIFE SCIENCES, 1991, 48 (13) : 1241 - 1245