Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence

被引：12
|
作者：
Endoh, Morio [1 ]
Kobayashi, Yusuke [1 ]
Yamakami, Yoshimi [1 ]
Yonekura, Ryuzo [1 ]
Fujii, Michihiko [1 ]
Ayusawa, Dai [1 ]
机构：
[1] Yokohama City Univ, Int Grad Sch Arts & Sci, Kanazawa Ku, Kanagawa 2360027, Japan
来源：
BIOGERONTOLOGY | 2009年 / 10卷 / 02期
关键词：
Pregnancy-specific glycoproteins; Cellular senescence; 5-Bromodeoxyuridine; Stress response; Gene expression; HELA-CELLS; MAMMALIAN-CELLS; IN-VIVO; 5-BROMODEOXYURIDINE; INDUCTION; SP1; IL-6; DNA; BETA-1-GLYCOPROTEIN; TROPHOBLAST;
D O I：
10.1007/s10522-008-9173-3
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Pregnancy-specific glycoproteins (PSGs) comprise a family of highly similar polypeptides encoded by 11 transcriptionally active genes that compactly cluster on band 19q13.2. All members of the PSG family were found to be markedly up-regulated by addition of 5-bromodeoxyuridine in HeLa cells. Similarly, all of the members were markedly up-regulated during replicative senescence in normal human fibroblasts. Promoter analysis of the PSG1, 4, and 11 genes in HeLa cells did not reveal a cis-regulatory element responsive to 5-bromodeoxyuridine in their 5'-flanking sequences. These results suggest that the PSG genes are regulated at a level of higher order chromatin structure besides by a signal of pregnancy.
引用
收藏
页码：213 / 221
页数：9
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