Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence

被引：12
|
作者：
Endoh, Morio [1 ]
Kobayashi, Yusuke [1 ]
Yamakami, Yoshimi [1 ]
Yonekura, Ryuzo [1 ]
Fujii, Michihiko [1 ]
Ayusawa, Dai [1 ]
机构：
[1] Yokohama City Univ, Int Grad Sch Arts & Sci, Kanazawa Ku, Kanagawa 2360027, Japan
来源：
BIOGERONTOLOGY | 2009年 / 10卷 / 02期
关键词：
Pregnancy-specific glycoproteins; Cellular senescence; 5-Bromodeoxyuridine; Stress response; Gene expression; HELA-CELLS; MAMMALIAN-CELLS; IN-VIVO; 5-BROMODEOXYURIDINE; INDUCTION; SP1; IL-6; DNA; BETA-1-GLYCOPROTEIN; TROPHOBLAST;
D O I：
10.1007/s10522-008-9173-3
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Pregnancy-specific glycoproteins (PSGs) comprise a family of highly similar polypeptides encoded by 11 transcriptionally active genes that compactly cluster on band 19q13.2. All members of the PSG family were found to be markedly up-regulated by addition of 5-bromodeoxyuridine in HeLa cells. Similarly, all of the members were markedly up-regulated during replicative senescence in normal human fibroblasts. Promoter analysis of the PSG1, 4, and 11 genes in HeLa cells did not reveal a cis-regulatory element responsive to 5-bromodeoxyuridine in their 5'-flanking sequences. These results suggest that the PSG genes are regulated at a level of higher order chromatin structure besides by a signal of pregnancy.
引用
收藏
页码：213 / 221
页数：9
相关论文
共 50 条
  • [21] PREGNANCY-SPECIFIC GLYCOPROTEIN (PSG) IN THE NORMAL AND AZOOSPERMIC HUMAN TESTIS
    CHAN, WY
    VORNBERGER, W
    BLOMBERG, LA
    SUAREZQUIAN, CA
    BIOLOGY OF REPRODUCTION, 1994, 50 : 91 - 91
  • [22] Gene expression in replicative senescence in human diploid fibroblasts
    Ghandhi, S
    Hubbard, K
    GERONTOLOGIST, 2004, 44 : 7 - 7
  • [23] PREGNANCY-SPECIFIC GLYCOPROTEIN GENE-EXPRESSION AND THE INDUCTION BY 5-BROMO-2'-DEOXYURIDINE
    PAN, CJ
    CHAMBERLIN, ME
    WU, SM
    CHAN, WY
    CHOU, JY
    BIOCHEMISTRY, 1994, 33 (23) : 7260 - 7266
  • [24] INVITRO EXPRESSION OF HUMAN PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN (PSG) IN CHO CELLS
    WU, SM
    TEASE, LA
    CHAN, WY
    FASEB JOURNAL, 1992, 6 (01): : A231 - A231
  • [25] Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus
    Andrew S McLellan
    Beate Fischer
    Gabriela Dveksler
    Tomomi Hori
    Freda Wynne
    Melanie Ball
    Katsuzumi Okumura
    Tom Moore
    Wolfgang Zimmermann
    BMC Genomics, 6
  • [26] DISCORDANT SECRETION OF PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN AND HUMAN CHORIONIC-GONADOTROPIN DURING PREGNANCY
    BRAUNSTEIN, GD
    RASOR, JL
    WADE, ME
    FERTILITY AND STERILITY, 1979, 32 (04) : 496 - 497
  • [27] CHARACTERIZATION OF NEW MEMBERS OF THE PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN FAMILY
    CHAN, WY
    ZHENG, QX
    MCMAHON, J
    TEASE, LA
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 1991, 106 (02) : 161 - 170
  • [28] ROLE OF THE TRANSCRIPTION FACTOR C/EBP-BETA IN EXPRESSION OF A RAT PREGNANCY-SPECIFIC GLYCOPROTEIN GENE
    CHEN, HW
    LIN, BC
    CHEN, CL
    JOHNSON, PF
    CHOU, JY
    DNA AND CELL BIOLOGY, 1995, 14 (08) : 681 - 688
  • [29] Two waves of evolution in the rodent pregnancy-specific glycoprotein (Psg) gene family lead to structurally diverse PSGs
    Robert Kammerer
    Wolfgang Zimmermann
    BMC Genomics, 24
  • [30] Two waves of evolution in the rodent pregnancy-specific glycoprotein (Psg) gene family lead to structurally diverse PSGs
    Kammerer, Robert
    Zimmermann, Wolfgang
    BMC GENOMICS, 2023, 24 (01)
12345