New prenylated indole alkaloids from fungus Penicillium sp derived of mangrove soil sample

被引:41
|
作者
Yang, Bin [1 ]
Dong, Junde [1 ]
Lin, Xiuping [1 ]
Zhou, Xuefeng [1 ]
Zhang, Yanying [1 ]
Liu, Yonghong [1 ]
机构
[1] Chinese Acad Sci, South China Sea Inst Oceanol, Res Ctr Marine Microbes, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Beijing 100864, Peoples R China
基金
中国国家自然科学基金;
关键词
Penicillium sp; Prenylated indole alkaloids; Mangrovamides; X-ray diffraction; Anti-acetylcholinesterase activity; ASPERGILLUS-JAPONICUS; PARAHERQUAMIDE; BIOSYNTHESIS; MALBRANCHEAMIDE; MARCFORTINE; CELLS;
D O I
10.1016/j.tet.2014.04.043
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Three diprenylated indole alkaloids, mangrovamides A-C (1-3), featured a bicyclo [2.2.2] diazaoctane core and possessed a novel gamma-methyl proline and isoprene derived dimethyl gamma-pyrone functionalities hitherto unknown among the family of paraherquamides, were isolated from the fungus Penicillium sp., which was separated from a mangrove soil sample. The structures were elucidated based on NMR, X-ray, and CD methods. The possible biosynthetic pathway of these compounds is proposed. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3859 / 3863
页数:5
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