Effects of phorbol esters an insulin-induced activation of phosphatidylinositol 3-kinase glucose transport, and glycogen synthase in rat adipocytes

In rat adipocytes, phorbol ester-induced activation of PKC did not inhibit insulin signalling through IRS-1-dependent phosphatidylinositol (PI) 3-kinase activation, Moreover, phorbol esters alone provoked an increase in membrane PI 3-kinase activity, These findings may be relevant to the failure of phorbol esters to inhibit insulin effects on glucose transport and glycogen synthesis in rat adipocytes.