Effects of phorbol esters an insulin-induced activation of phosphatidylinositol 3-kinase glucose transport, and glycogen synthase in rat adipocytes

被引：15

作者：

Standaert, ML

Bandyopadhyay, G

Galloway, L

Farese, RV

机构：

[1] UNIV S FLORIDA,JA HALEY VET HOSP,RES SERV VAR151,TAMPA,FL 33612

[2] UNIV S FLORIDA,COLL MED,DEPT INTERNAL MED,TAMPA,FL 33612

[3] UNIV S FLORIDA,COLL MED,DEPT BIOCHEM,TAMPA,FL 33612

来源：

FEBS LETTERS | 1996年 / 388卷 / 01期

关键词：

insulin; phorbol ester; phosphatidylinositol; 3-kinase; glucose transport; adipocyte; IRS-1;

D O I：

10.1016/0014-5793(96)00492-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In rat adipocytes, phorbol ester-induced activation of PKC did not inhibit insulin signalling through IRS-1-dependent phosphatidylinositol (PI) 3-kinase activation, Moreover, phorbol esters alone provoked an increase in membrane PI 3-kinase activity, These findings may be relevant to the failure of phorbol esters to inhibit insulin effects on glucose transport and glycogen synthesis in rat adipocytes.

引用

页码：26 / 28

页数：3

共 50 条

[21] Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes - Apparent involvement of phosphatidylinositol 3-kinase
Karnam, P
Standaert, ML
Galloway, L
Farese, RV
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) : 6136 - 6140
[22] EFFECTS OF INSULIN AND METHOXAMINE ON GLYCOGEN SYNTHASE IN RAT ADIPOCYTES
LAWRENCE, JC
LARNER, J
FEDERATION PROCEEDINGS, 1978, 37 (06) : 1823 - 1823
[23] Impairment of the insulin-induced activation of the constitutive nitric oxide synthase via the phosphatidylinositol 3-kinase pathway in platelets from obese subjects.
Massucco, P
Mattiello, L
Traversa, M
Anfossi, G
Trovati, M
DIABETOLOGIA, 2003, 46 : A206 - A206
[24] ESSENTIAL ROLE OF PHOSPHATIDYLINOSITOL 3-KINASE IN INSULIN-INDUCED ACTIVATION AND PHOSPHORYLATION OF THE CGMP-INHIBITED CAMP-PHOSPHODIESTERASE IN RAT ADIPOCYTES - STUDIES USING THE SELECTIVE INHIBITOR WORTMANNIN
RAHN, T
RIDDERSTRALE, M
TORNQVIST, H
MANGANIELLO, V
FREDRIKSON, G
BELFRAGE, P
DEGERMAN, E
FEBS LETTERS, 1994, 350 (2-3) : 314 - 318
[25] Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes
Burén, J
Liu, HX
Jensen, J
Eriksson, JW
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2002, 146 (03) : 419 - 429
[26] Insulin-induced activation of phosphoinositide 3-kinase in Fao-cells
Hayashi, T
Okamoto, M
Yoshimasa, Y
Inoue, G
Yamada, K
Kono, S
Shigemoto, M
Suga, J
Kuzuya, H
Nakao, K
DIABETOLOGIA, 1996, 39 (05) : 515 - 522
[27] Insulin-induced activation of phospholipase D in rat adipocytes
Ishizawa, M
Ishizuka, T
Kanoh, Y
Miura, A
Kajita, K
Itaya, S
Kimura, M
Yamada, K
Yasuda, K
DIABETOLOGIA, 1997, 40 : 537 - 537
[28] Strain-induced Proliferation Requires the Phosphatidylinositol 3-Kinase/AKT/Glycogen Synthase Kinase Pathway
Gayer, Christopher P.
Chaturvedi, Lakshmi S.
Wang, Shouye
Craig, David H.
Flanigan, Thomas
Basson, Marc D.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (04) : 2001 - 2011
[29] Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes
Egawa, K
Nakashima, N
Sharma, PM
Maegawa, H
Nagai, Y
Kashiwagi, A
Kikkawa, R
Olefsky, JM
ENDOCRINOLOGY, 2000, 141 (06) : 1930 - 1935
[30] EFFECT OF THE ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE BY A THIOPHOSPHOTYROSINE PEPTIDE ON GLUCOSE-TRANSPORT IN 3T3-L1 ADIPOCYTES
HERBST, JJ
ANDREWS, GC
CONTILLO, LG
SINGLETON, DH
GENEREUX, PE
GIBBS, EM
LIENHARD, GE
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (43) : 26000 - 26005

← 1 2 3 4 5 →