Effects of phorbol esters an insulin-induced activation of phosphatidylinositol 3-kinase glucose transport, and glycogen synthase in rat adipocytes

被引：15
|
作者：
Standaert, ML
Bandyopadhyay, G
Galloway, L
Farese, RV
机构：
[1] UNIV S FLORIDA,JA HALEY VET HOSP,RES SERV VAR151,TAMPA,FL 33612
[2] UNIV S FLORIDA,COLL MED,DEPT INTERNAL MED,TAMPA,FL 33612
[3] UNIV S FLORIDA,COLL MED,DEPT BIOCHEM,TAMPA,FL 33612
来源：
FEBS LETTERS | 1996年 / 388卷 / 01期
关键词：
insulin; phorbol ester; phosphatidylinositol; 3-kinase; glucose transport; adipocyte; IRS-1;
D O I：
10.1016/0014-5793(96)00492-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In rat adipocytes, phorbol ester-induced activation of PKC did not inhibit insulin signalling through IRS-1-dependent phosphatidylinositol (PI) 3-kinase activation, Moreover, phorbol esters alone provoked an increase in membrane PI 3-kinase activity, These findings may be relevant to the failure of phorbol esters to inhibit insulin effects on glucose transport and glycogen synthesis in rat adipocytes.
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页码：26 / 28
页数：3
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