Prediction of the induction potential of drug candidates in primary human hepatocytes:: In vitro regulation of human cytochrome P450 and clinical outcome

被引：0
|
作者：
Kern, A
Möller, JG
Lang, D
Thasler, WE
Bader, A
机构：
[1] Bayer AG, D-42096 Wuppertal, Germany
[2] Univ Regensburg Hosp, Ctr Liver Cell Res, D-93042 Regensburg, Germany
[3] Univ Tubingen, D-72074 Tubingen, Germany
来源：
DRUG METABOLISM REVIEWS | 2002年 / 34卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
245
引用
收藏
页码：123 / 123
页数：1
相关论文
共 50 条
  • [31] In Vitro Inhibition and Induction of Human Liver Cytochrome P450 Enzymes by Milnacipran
    Paris, Brandy L.
    Ogilvie, Brian W.
    Scheinkoenig, Julie A.
    Ndikum-Moffor, Florence
    Gibson, Remi
    Parkinson, Andrew
    DRUG METABOLISM AND DISPOSITION, 2009, 37 (10) : 2045 - 2054
  • [32] In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil
    Robertson, P
    Decory, HH
    Madan, A
    Parkinson, A
    DRUG METABOLISM AND DISPOSITION, 2000, 28 (06) : 664 - 671
  • [33] Characterization of human cytochrome P450 induction by pesticides
    Abass, Khaled
    Lamsa, Virpi
    Reponen, Petri
    Kublbeck, Jenni
    Honkakoski, Paavo
    Mattila, Sampo
    Pelkonen, Olavi
    Hakkola, Jukka
    TOXICOLOGY, 2012, 294 (01) : 17 - 26
  • [34] Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes
    Sahi, J
    Hamilton, G
    Sinz, M
    Barros, S
    Huang, SM
    Lesko, LJ
    LeCluyse, EL
    XENOBIOTICA, 2000, 30 (03) : 273 - 284
  • [35] In vitro inhibition and induction of human cytochrome P450 enzymes by SIPI5357, a potential antidepressant
    Fan, Gaoning
    Cao, Yun
    Yang, Jin
    BIOPHARMACEUTICS & DRUG DISPOSITION, 2015, 36 (06) : 364 - 372
  • [36] In Vitro Investigations into the Potential Drug Interactions of Pseudoginsenoside DQ Mediated by Cytochrome P450 and Human Drug Transporters
    Li, Zhuo
    Wang, Cuizhu
    Liu, Jinping
    Li, Pingya
    Feng, Hao
    MOLECULES, 2024, 29 (11):
  • [37] In vitro effects of tacrolimus on human cytochrome P450
    Lecointre, K
    Furlan, V
    Taburet, AM
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2002, 16 (06) : 455 - 460
  • [38] In vitro inhibition of human cytochrome P450 by cudratricusxanthone A
    Sim, Juhee
    Choi, Eunhwa
    Lee, You-Mie
    Jeong, Gil-Saeng
    Lee, Sangkyu
    FOOD AND CHEMICAL TOXICOLOGY, 2015, 81 : 171 - 175
  • [39] In vitro evaluation of the inhibition potential of echinacoside on human cytochrome P450 isozymes
    Wu, Yujie
    Qiao, Aiqing
    Lin, Shu
    Chen, Lijia
    BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2022, 22 (01)
  • [40] In vitro evaluation of the inhibition potential of echinacoside on human cytochrome P450 isozymes
    Yujie Wu
    Aiqing Qiao
    Shu Lin
    Lijia Chen
    BMC Complementary Medicine and Therapies, 22
12345