Prediction of the induction potential of drug candidates in primary human hepatocytes:: In vitro regulation of human cytochrome P450 and clinical outcome

被引:0
|
作者
Kern, A
Möller, JG
Lang, D
Thasler, WE
Bader, A
机构
[1] Bayer AG, D-42096 Wuppertal, Germany
[2] Univ Regensburg Hosp, Ctr Liver Cell Res, D-93042 Regensburg, Germany
[3] Univ Tubingen, D-72074 Tubingen, Germany
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
245
引用
收藏
页码:123 / 123
页数:1
相关论文
共 50 条
  • [21] Inhibition and induction of human cytochrome P450 enzymes in vitro by capsaicin
    Babbar, Sunita
    Chanda, Sanjay
    Bley, Keith
    XENOBIOTICA, 2010, 40 (12) : 807 - 816
  • [22] Miniturization of a primary human hepatocyte cytochrome P450 induction model
    Day, SH
    Nicoll-Griffith, DA
    Silva, JM
    MOLECULAR BIOLOGY OF THE CELL, 1998, 9 : 125A - 125A
  • [23] Regulation of Cytochrome P450 2C9 Expression in Primary Cultures of Human Hepatocytes
    Sahi, Jasminder
    Shord, Stacy S.
    Lindley, Celeste
    Ferguson, Stephen
    LeCluyse, Edward L.
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2009, 23 (01) : 43 - 58
  • [24] In vitro assessment of human cytochrome P450
    Clarke, SE
    XENOBIOTICA, 1998, 28 (12) : 1167 - 1202
  • [25] Prediction of seriniquinone-drug interactions by in vitro inhibition of human cytochrome P450 enzymes
    da Silva, Rodrigo Moreira
    Carrao, Daniel Blascke
    Habenschus, Maisa Daniela
    Jimenez, Paula Christine
    Lops, Norberto Peporine
    Fenical, William
    Costa-Lotufo, Leticia Vera
    Moraes de Oliveira, Anderson Rodrigo
    TOXICOLOGY IN VITRO, 2020, 65
  • [26] Determination of cytochrome P450 1A2 and cytochrome P450 3A4 induction in cryopreserved human hepatocytes
    Roymans, D
    Van Looveren, C
    Leone, A
    Parker, JB
    McMillian, M
    Johnson, MD
    Koganti, A
    Gilissen, R
    Silber, P
    Mannens, G
    Meuldermans, W
    BIOCHEMICAL PHARMACOLOGY, 2004, 67 (03) : 427 - 437
  • [27] The utility of cold-preserved human hepatocytes in studies on cytochrome P450 induction and hepatic drug transport
    Juric, Sanja
    Lundquist, Patrik
    Hu, Yin
    Jureus, Anna
    Sohlenius-Sternbeck, Anna-Karin
    XENOBIOTICA, 2013, 43 (09) : 785 - 791
  • [28] Induction, expression and maintenance of cytochrome P450 isoforms in long-term cultures of primary human hepatocytes
    Yuan, J
    Liu, LG
    Shimada, M
    Wang, AG
    Ruhnke, M
    Heeckt, P
    Muller, AR
    Nussler, NC
    Neuhaus, R
    Nussler, A
    ALTEX-ALTERNATIVEN ZU TIEREXPERIMENTEN, 2004, 21 : 3 - 11
  • [29] Regulation of cytochrome P450 in a primary culture of rainbow trout hepatocytes
    Sadar, MD
    Andersson, TB
    IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2001, 37 (03) : 180 - 184
  • [30] Regulation of cytochrome P450 in a primary culture of rainbow trout hepatocytes
    Sadar M.D.
    Andersson T.B.
    In Vitro Cellular & Developmental Biology - Animal, 2001, 37 (3) : 180 - 184