Absolute Stereochemical Determination of Asymmetric Sulfoxides via Central to Axial Induction of Chirality

被引：18

作者：

Gholami, Hadi ^{[1
]}

Zhang, Jun ^{[1
]}

Anyika, Mercy ^{[1
]}

Borhan, Babak ^{[1
]}

机构：

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 07期

关键词：

VIBRATIONAL CIRCULAR-DICHROISM; OPTICALLY-ACTIVE SULFOXIDES; METHYL SULFOXIDE; CONFIGURATION; SPECTROSCOPY; NMR;

D O I：

10.1021/acs.orglett.7b00495

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The absolute configuration of chiral sulfoxides is determined, by means of host-guest complexation that leads to the induction of axial chirality in an achiral host. The central to axial induction, of helicity is rationalized by a simple recognition, of the relative length and size of the substituents attached to the S-center. This technique is used to determine the absolute configuration of chiral sulfoxides, requiring micrograms of sample, without the need for prefunctionalization.

引用

页码：1722 / 1725

页数：4

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